ArticleeLife2023
Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Mapping Functional Brain Organization Using Artificial Intelligence.Chemical & biomedical imaging · 2026Review
- Functional changes of precuneus architecture across newborns, infants, and early adolescents.Scientific reports · 2026Article
- Hierarchical maturation of structural brain connectomes from birth to childhood.Nature communications · 2026Article
- Decreased Cerebral Blood Flow in Young Children With Prenatal Alcohol Exposure.Biological psychiatry global open science · 2025Article
- Spatial development of brain networks during the first six postnatal months.Communications biology · 2025Article
- Social Smiling and Laughter Are Linked to Enhanced Functional Brain Connectivity in Young Infants' Default Mode Network.Developmental psychobiology · 2025Article
- Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan.PLoS biology · 2025Article
- The overgrowth of structure-function coupling in premature brain during infancy.Developmental cognitive neuroscience · 2025Article
- Alteration in Cortical Structure Mediating the Impact of Blood Oxygen-Carrying Capacity on Gross Motor Skills in Infants With Complex Congenital Heart Disease.Human brain mapping · 2025Article
- Article
- Cognitive deterioration in patients undergoing hemodialysis: how variations in age influence the development of new mechanisms and treatment approaches?Frontiers in aging neuroscience · 2025Review
- Machine-learning based prediction of future outcome using multimodal MRI during early childhood.Seminars in fetal & neonatal medicine · 2024Review
- Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy.Research square · 2024Article
- Diffusion-tensor-imaging 1-year-old and 2-year-old infant brain atlases with comprehensive gray and white matter labels.Human brain mapping · 2024Article
- Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy.bioRxiv : the preprint server for biology · 2024Article
- Association between ASL MRI-derived cerebral blood flow and outcomes after pediatric cardiac arrest.Resuscitation · 2024Observational
- Development of sensorimotor-visual connectome gradient at birth predicts neurocognitive outcomes at 2 years of age.iScience · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Human infancy is characterized by most rapid regional cerebral blood flow (rCBF) increases across lifespan and emergence of a fundamental brain system default-mode network (DMN). However, how infant rCBF changes spatiotemporally across the brain and how the rCBF increase supports emergence of functional networks such as DMN remains unknown. Here, by acquiring cutting-edge multi-modal MRI including pseudo-continuous arterial-spin-labeled perfusion MRI and resting-state functional MRI of 48 infants cross-sectionally, we elucidated unprecedented 4D spatiotemporal infant rCBF framework and region-specific physiology-function coupling across infancy. We found that faster rCBF increases in the DMN than visual and sensorimotor networks. We also found strongly coupled increases of rCBF and network strength specifically in the DMN, suggesting faster local blood flow increase to meet extraneuronal metabolic demands in the DMN maturation. These results offer insights into the physiological mechanism of brain functional network emergence and have important implications in altered network maturation in brain disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.