Evidence map›Paper›PMID 36692682›Full record

ArticleEJNMMI research2023

Optimization of the radiation dosimetry protocol in Lutetium-177-PSMA therapy: toward clinical implementation.

Steffie M B Peters, Maaike C T Mink, Bastiaan M Privé, Maarten de Bakker, Frank de Lange, Constantijn H J Muselaers, Niven Mehra, J Alfred Witjes, Martin Gotthardt, James Nagarajah and 1 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Outcome-driven dosimetry optimization for [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Review
  4. PROQURE-I: a phase I study adding concurrent [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Inter-center variability of dosimetry methodology and the impact on reported absorbed dose for [European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Validation of Simplified Renal Dosimetry Protocols forMolecular imaging and radionuclide therapy · 2026
    Article
  7. Article
  8. Future of radiotheranostics.BMJ oncology · 2026
    Review
  9. Design and Evaluation of a Portable Pinhole SPECT System forDiagnostics (Basel, Switzerland) · 2025
    Article
  10. Characterization of Effective Half-Life for Instant Single-Time-Point Dosimetry Using Machine Learning.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Impact of the Reference Multiple-Time-Point Dosimetry Protocol on the Validity of Single-Time-Point Dosimetry for [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Steffie M B Peters *Department of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. steffie.peters@radboudumc.nl.ORCID http://orcid.org/0000-0002-0752-7134
Maaike C T Mink *Department of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Bastiaan M PrivéDepartment of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Maarten de BakkerDepartment of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Frank de LangeDepartment of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Constantijn H J MuselaersDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Niven MehraDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
J Alfred WitjesDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Martin GotthardtDepartment of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
James Nagarajah *Department of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Mark W Konijnenberg *Department of Medical Imaging, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDosimetry in [

methodsTen patients with metastatic hormone-sensitive prostate cancer received two cycles of [

resultsAccurate lesion dosimetry is possible using one-time point SPECT imaging at 168 h, with an increase in uncertainty (20% vs. 14% for the reference standard). By including a second time point, uncertainty was comparable to the reference standard (13%). Organ dosimetry can be performed using a single SPECT at 24 h or 48 h. Dosimetry based on planar scans did not provide accurate dose estimations.

conclusionAccurate lesion dosimetry in [

Indexed as

[177Lu]Lu-PSMADosimetrymHSPCProstate cancerRadionuclide therapy

Identifiers

PMID36692682
PMCPMC9873880
OpenAlexW4317869433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.