Evidence map›Paper›PMID 36692642›Full record

SynthesisClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2023

The prognostic values of FOXP3

Yalan Sun, Ying Wang, Fang Lu, Xianghong Zhao, Zhenlin Nie, Bangshun He

Abstract readMeta-AnalysisSystematic Review
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In one paragraph

Synthesis in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yalan Sun *School of Basic-Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Ying Wang *School of Basic-Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Fang LuSchool of Basic-Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Xianghong ZhaoSchool of Basic-Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Zhenlin NieDepartment of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China. Zhenlinnie@126.com.
Bangshun HeSchool of Basic-Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China. bhe@njmu.edu.cn.ORCID http://orcid.org/0000-0002-4731-0167

Funding

National Science Foundation of China 81902143
6 · The paper itself

Abstract

backgroundTumor microenvironment is infiltrated by many immune cells, of which Regulatory T (Treg) cells are usually considered as negative regulators of the immune responses. However, the effect of FOXP3

methodsAfter systematic retrieval of all relevant studies, 28 eligible articles were identified for meta-analysis. Odd ratio (OR), hazard ratio (HR), and 95% confidence interval (CI) were obtained for pooled analyses of pathological complete response (pCR), overall survival (OS), and corresponding forest plots and funnel plots were plotted, respectively.

resultsPooled results revealed that patients with higher levels of FOXP3

conclusionsThe predictive role of FOXP3

Indexed as

Breast NeoplasmsTriple Negative Breast NeoplasmsFemaleForkhead Transcription FactorsHumansLymphocytes, Tumor-InfiltratingPrognosisT-Lymphocytes, RegulatoryTumor MicroenvironmentForkhead Transcription FactorsFOXP3 protein, humanBreast cancerFOXP3+ Treg cellsMeta-analysisPrognosis

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.