ReviewSkeletal radiology2023
Biomarkers in osteoarthritis: current status and outlook - the FNIH Biomarkers Consortium PROGRESS OA study.
Review in Skeletal radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Molecular hydrogen and osteoarthritis: multi-target mechanisms and therapeutic effectiveness.Medical gas research · 2027Review
- Evaluating the utility of prognostic enrichment in clinical trials: Applications to clinical trial design in osteoarthritis.Osteoarthritis and cartilage · 2026Article
- RBP4-a risk factor in lipid metabolism-serves as an early diagnostic and prognostic marker of knee osteoarthritis progression.Arthritis research & therapy · 2026Article
- Article
- Influence of major trauma and lower limb loss on radiographic progression and incidence of knee osteoarthritis and pain: a comparative and predictive analysis from the ADVANCE study.Arthritis research & therapy · 2026Article
- Focus on the NLRP3 inflammasome: its role in the pathogenesis and therapeutic potential of inflammation-driven osteoarthritis.Frontiers in immunology · 2026Review
- Production of a risk mitigation matrix and four-grade threshold scale using Cox Regression to predict osteoarthritis development.Open life sciences · 2026Article
- The osteoarthritis inflammatory ecosystem: a node-edge-boundary-emergent framework toward precision stratification and therapeutic hypothesis generation.Frontiers in medicine · 2026Review
- The role of radiography and MRI as screening tools and outcome measures in clinical trials of knee osteoarthritis: a perspective on the current status and outlook.Therapeutic advances in musculoskeletal disease · 2026Review
- Article
- Biochemical biomarkers of knee osteoarthritis progression: Results from the FNIH biomarkers consortium progress OA study.Osteoarthritis and cartilage open · 2025Article
- A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention.International journal of molecular sciences · 2025Review
- Insights into knee post-traumatic osteoarthritis pathophysiology from the relationship of serum biomarkers to radiographic features in the ADVANCE cohort.Arthritis research & therapy · 2025Article
- TurkerNeXtV2: An Innovative CNN Model for Knee Osteoarthritis Pressure Image Classification.Diagnostics (Basel, Switzerland) · 2025Article
- Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation - Data from the FNIH biomarker cohort.Osteoarthritis and cartilage open · 2025Article
- Magnetic Resonance Imaging Biomarkers of Knee Osteoarthritis Progression.ACR open rheumatology · 2025Article
- Multifaceted imaging strategies for clinical trials of knee osteoarthritis-a tightly interlinked value and precision chain.Skeletal radiology · 2025Review
- Deconstructing the "types" of osteoarthritis.Osteoarthritis imaging · 2025Article
- Associations of Longitudinal Multiparametric MRI Findings and Clinical Outcomes in Intra-Articular Injections for Knee Osteoarthritis.Diagnostics (Basel, Switzerland) · 2024Article
- Prognostic value of B-score for predicting joint replacement in the context of osteoarthritis phenotypes: Data from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints' limited validity and responsiveness. To overcome this impasse, the Foundation for the NIH OA Biomarkers Consortium is focused on investigating biomarkers for a prognostic context of use for subsequent qualification through regulatory agencies. This narrative review describes this activity and the work underway, focusing on the PROGRESS OA study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.