Evidence map›Paper›PMID 36692300›Full record

ArticleMicrobiology spectrum2023

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control.

Pauline Trémeaux, Frédéric Lemoine, Adeline Mélard, Marine Gousset, Faroudy Boufassa, Sylvie Orr, Valérie Monceaux, Olivier Gascuel, Olivier Lambotte, Laurent Hocqueloux and 3 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Pauline TrémeauxUniversité Paris Cité, Faculté de Médecine, Paris, France.ORCID 0000-0001-8783-9885
Frédéric LemoineInstitut Pasteur, Université de Paris, Unité Bio-informatique Evolutive, Paris, France.
Adeline MélardUniversité Paris Cité, Faculté de Médecine, Paris, France.
Marine GoussetUniversité Paris Cité, Faculté de Médecine, Paris, France.
Faroudy BoufassaINSERM CESP U1018, Université Paris Sud, Le Kremlin Bicêtre, France.
Sylvie OrrINSERM CESP U1018, Université Paris Sud, Le Kremlin Bicêtre, France.
Valérie MonceauxInstitut Pasteur, HIV Inflammation et Persistance, Paris, France.
Olivier GascuelInstitut Pasteur, Université de Paris, Unité Bio-informatique Evolutive, Paris, France.
Olivier LambotteAP-HP, Hôpital Bicêtre, UMR1184, Université Paris Saclay, Inserm, CEA, Le Kremlin Bicêtre, France.
Laurent HocquelouxService des Maladies Infectieuses et Tropicales, CHR d'Orléans-La Source, Orléans, France.
Asier Saez-CirionInstitut Pasteur, HIV Inflammation et Persistance, Paris, France.ORCID 0000-0003-2406-7536
Christine RouziouxUniversité Paris Cité, Faculté de Médecine, Paris, France.
Véronique Avettand-FenoelUniversité Paris Cité, Faculté de Médecine, Paris, France.ORCID 0000-0002-7022-2990
Institut Pasteur · FRCentre hospitalier universitaire d'Orléans · FRInserm · FRUniversité Paris-Sud · FRCentre National de la Recherche Scientifique · FRUniversité Paris Cité · FRHôpital Necker-Enfants Malades · FR

Funding

Viral dynamics of rebound and control following early treatment of HIV/SIVP01AI131365 · NIAID · BOSTON COLLEGE · PI WHITNEY, JAMES BURTON · 2017 to 2021
$7.5M
NIAID NIH HHS P01 AI131365
6 · The paper itself

Abstract

In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission. To better understand their mechanisms of control, we characterized the HIV blood reservoirs of 8 PTCs (median of 9.4 years after treatment interruption) in comparison with those of 13 natural HIV infection controllers (HICs) (median of 18 years of infection) and with those of individuals receiving efficient antiretroviral therapy initiated during either primary HIV infection (PHIs;

Indexed as

HIV-1HIV InfectionsCD4-Positive T-LymphocytesGenome, ViralHumansLeukocytes, MononuclearProvirusesViral Loaddefective provirusesHIV reservoirsnext-generation sequencingposttreatment HIV controllerposttreatment HIV controllersprovirusprovirusesultradeep sequencing

Identifiers

PMID36692300
PMCPMC9927157
OpenAlexW4317871140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.