Evidence map›Paper›PMID 36692262›Full record

ArticleeLife2023

Hierarchical architecture of dopaminergic circuits enables second-order conditioning in

Daichi Yamada, Daniel Bushey, Feng Li, Karen L Hibbard, Megan Sammons, Jan Funke, Ashok Litwin-Kumar, Toshihide Hige, Yoshinori Aso

Abstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Dual roles ofiScience · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Diverse memory paradigms inLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  11. Review
  12. Cognitive limits of larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Connectomics and the neural basis of behaviour.Current opinion in insect science · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daichi YamadaDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-4944-1950
Daniel BusheyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-9258-6579
Feng LiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-6658-9175
Karen L HibbardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-2001-6099
Megan SammonsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-4516-5928
Jan FunkeJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-4388-7783
Ashok Litwin-KumarDepartment of Neuroscience, Columbia University, New York, United States.ORCID 0000-0003-2422-6576
Toshihide HigeDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0002-0007-3192
Yoshinori AsoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-2939-1688

Funding

Molecular and circuit mechanisms of learning supported by heterogeneous dopaminergic neuronsR01DC018874 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TOSHIHIDE HIGE · 2021 to 2026
$1.6M
Relating structure and function in synapse-level wiring diagramsR01EB029858 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LITWIN-KUMAR, ASHOK · 2020 to 2020
$1.2M
Howard Hughes Medical InstituteNIBIB NIH HHS R01 EB029858NIDCD NIH HHS R01 DC018874NIH HHS R01DC018874NIH HHS R01EB029858
6 · The paper itself

Abstract

Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify a feedforward circuit formed between dopamine subsystems and show that it is essential for second-order conditioning, an ethologically important form of higher-order associative learning. The

Indexed as

DopamineDrosophilaAnimalsBrainDopaminergic NeuronsDrosophila melanogasterLearningMushroom BodiesOdorantsSmellDopamineassociative learningD. melanogasterdopamineEM connectomehigher order conditioningmushroom bodyneural circuitsneuroscience

Identifiers

PMID36692262
PMCPMC9937650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.