Evidence map›Paper›PMID 36692207›Full record

ArticleInternational journal of epidemiology2023

In-utero exposure to antibiotics and risk of colorectal cancer in a prospective cohort of 18 000 adult offspring.

Caitlin C Murphy, Piera M Cirillo, Nickilou Y Krigbaum, Amit G Singal, Dean P Jones, Timothy Zaki, Barbara A Cohn

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Father's occupation and colorectal cancer in his adult offspring.Journal of the National Cancer Institute · 2025
    Article
  4. Article
  5. Article
  6. Birth Cohort Colorectal Cancer (CRC): Implications for Research and Practice.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Caitlin C MurphyDepartment of Health Promotion and Behavioral Sciences, University of Texas Health Science Center at Houston (UTHealth Houston), School of Public Health, Houston, TX, USA.ORCID 0000-0001-9365-0691
Piera M CirilloChild Health and Development Studies, Public Health Institute, Berkeley, CA, USA.
Nickilou Y KrigbaumChild Health and Development Studies, Public Health Institute, Berkeley, CA, USA.
Amit G SingalDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1172-3971
Dean P JonesDepartments of Medicine and Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Timothy ZakiDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Barbara A CohnChild Health and Development Studies, Public Health Institute, Berkeley, CA, USA.
Public Health Institute · USThe University of Texas Southwestern Medical Center · USEmory University · USThe University of Texas Health Science Center at Houston · US

Funding

Early life exposures and risk of young-onset colorectal cancerR01CA242558 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MURPHY, CAITLIN C · 2019 to 2023
$1.5M
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS R01 CA242558NICHD NIH HHS HHSN275201100020CNIH HHS HHSN275201100020C
6 · The paper itself

Abstract

backgroundIncidence rates of colorectal cancer (CRC) are increasing among younger adults and in mid-life, implicating exposures in early life as risk factors. We examined the association between in-utero exposure to antibiotics and risk of CRC in adult offspring.

methodsThe Child Health and Development Studies is a prospective cohort of women receiving prenatal care between 1959 and 1966 in Oakland, California, with deliveries through June 1967. Diagnosed conditions and all prescribed medications were abstracted from mothers' medical records beginning 6 months prior to pregnancy through delivery. We identified mothers who received antibiotics in pregnancy, including penicillins, tetracyclines, short-acting sulfonamides and long-acting sulfonamides. Diagnoses of CRC in adult (age ≥18 years) offspring were ascertained through 2021 by linkage with the California Cancer Registry. Cox proportional models were used to estimate adjusted hazard ratios (aHR), with follow-up accrued from birth through cancer diagnosis, death or last contact.

resultsOf 18 751 liveborn offspring, about 15% (n = 2635) were exposed in utero to antibiotics: 5.4% (n = 1016) to tetracyclines, 4.9% (n = 918) to penicillins, 4.2% (n = 785) to short-acting sulfonamides and 1.5% (n = 273) to long-acting sulfonamides. Compared with offspring not exposed, associations between in-utero exposure and CRC in adult offspring were: aHR 1.03 (95% CI 0.32, 3.31) for tetracyclines; aHR 1.12 (95% CI 0.35, 3.58) for penicillins; aHR 0.83 (95% CI 0.20, 3.42) for short-acting sulfonamides; and aHR 4.40 (95% CI 1.63, 11.88) for long-acting sulfonamides.

conclusionOur findings support an association between in-utero exposure to long-acting sulfonamides and CRC in adulthood.

Indexed as

Colorectal NeoplasmsPrenatal Exposure Delayed EffectsAdolescentAdultAdult ChildrenAnti-Bacterial AgentsChildFemaleHumansPenicillinsPregnancyProspective StudiesSulfanilamideTetracyclinesAnti-Bacterial AgentsPenicillinsSulfanilamideTetracyclinesantimicrobial agentColorectal cancerrisk factoryoung adult

Identifiers

PMID36692207
PMCPMC10555902
OpenAlexW4317869470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.