ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023
Day-night patterns in heart rate variability and complexity: differences with age and cardiopulmonary disease.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Physiological signal entropy in patients with chronic respiratory disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Association between environmental and headphone noise and heart rate variability: observations from Apple Hearing Study cohort.Journal of exposure science & environmental epidemiology · 2026Article
- Circadian regulation of cardiovascular function: from physiology to clinical implications.Genome medicine · 2026Review
- Vagal modulation in pediatric disorders of gut-brain interaction: the role of 24 h heart rate variability.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Association of daily lung condition in COPD patients with wearable speech and physiological data.Scientific reports · 2025Article
- Assessment of Sleep-wake State-associated Dynamic Changes in Heart Rate Variability in Female Rat: Autonomic System Modelling Approaches for Studying Behavioural Dysregulation.Annals of neurosciences · 2025Article
- Circadian Rhythm Disruptions and Cardiovascular Disease Risk: The Special Role of Melatonin.Current issues in molecular biology · 2025Review
- Patterns of heart rate reduction during sleep onset in participants with and without insomnia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Article
- Heart Rate Variability (HRV) in Patients with Sleep Apnea and COPD: A Comprehensive Analysis.Journal of clinical medicine · 2025Review
- Article
- Circadian rhythm of heart rate and heart rate variability in pregnancy.npj women's health · 2025Article
- The ProCVT smart-sheet as a new screening tool for cardiovascular autonomic neuropathy: a feasibility study.Frontiers in endocrinology · 2025Article
- Heart rate variability during sleep onset in patients with insomnia with or without comorbid sleep apnea.Sleep medicine · 2024Article
- Associations between Sleep Duration and Autonomic Nervous System Regulation in Patients with Probable Alzheimer's Disease: A Cross-Sectional Pilot Study.Clocks & sleep · 2024Article
- Different implications of daytime and nighttime heart rate variability on total burden of cerebral small vascular disease in patients with nondisabling ischemic cerebrovascular events.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesHeart rate variability (HRV) measures provide valuable insights into physiology; however, gaps remain in understanding circadian patterns in heart rate dynamics. We aimed to explore day-night differences in heart rate dynamics in patients with chronic cardiopulmonary disease compared with healthy controls.
methodsUsing 24-hour heart rate data from patients with chronic obstructive pulmonary disease (COPD) and/or heart failure (n = 16) and healthy adult controls (older group: ≥50 years, n = 42; younger group: 20-49 years, n = 136), we compared day-night differences in conventional time and frequency domain HRV indices and a multiscale-entropy-based complexity index (CI
resultsTwenty-four-hour HRV showed significant day-night differences (marked with "△") among younger healthy (mean age: 34.5 years), older healthy (mean age: 61.6 years), and cardiopulmonary patients (mean age: 68.4 years), including change in percentage of adjacent intervals that differ > 50 ms (△pNN50), high frequency (△HF), normalized low frequency (△nLF), ratio (△LF/HF), and △CI
conclusionsAs measures of 24-hour variability, traditional and complexity-based metrics of HRV exhibit large day-night differences in healthy individuals; these differences are blunted, or even reversed, in individuals with cardiopulmonary pathology. Measures of diurnal dynamics may be useful indices of reduced adaptive capacity in patients with cardiopulmonary conditions. CITATION: Ma Y, Chang M-C, Litrownik D, Wayne PM, Yeh GY. Day-night patterns in heart rate variability and complexity: differences with age and cardiopulmonary disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.