ArticleAnnals of surgery2023
The High Incidence of Occult Carcinoma in Total Hepatectomy Specimens of Patients Treated for Unresectable Colorectal Liver Metastases With Liver Transplant.
Article in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Long-term Outcomes After Resection of Solitary Colorectal Liver Metastases.Annals of surgical oncology · 2026Article
- Surgical Resection for Colorectal Liver Metastasis in Elderly Patients Aged ≥ 80: A Retrospective Nationwide Cohort Survey in Japan With Propensity Score Matching.Annals of gastroenterological surgery · 2026Article
- Revisiting treatment paradigms for colorectal liver metastases: liver transplant or associating liver partition and portal vein ligation for staged hepatectomy?Hepatobiliary surgery and nutrition · 2026Article
- Disappearing colorectal liver metastases: the importance of radiographic-pathologic correlation in oncology care.Hepatobiliary surgery and nutrition · 2025Article
- Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature.Current oncology (Toronto, Ont.) · 2024Review
- Update to 'A Contemporary Systematic Review on Liver Transplantation for Unresectable Liver Metastasis of Colorectal Cancer'.Annals of surgical oncology · 2024Article
- Epidemiological Situation of High-Prevalence Non-Communicable Diseases in Spain: A Systematic Review.Journal of clinical medicine · 2023Review
- Article
- Liver Transplantation for Unresectable Colorectal Liver Metastases.Technology in cancer research & treatmentReview
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the rate of occult carcinoma deposits in total hepatectomy specimens from patients treated with liver transplant (LT) for colorectal liver metastases (CRLM).
backgroundPrevious studies have shown that patients with CRLM treated with systemic therapy demonstrate a high rate of complete radiographic response or may have disappearing liver metastases. However, this does not necessarily translate into a complete pathologic response, and residual invasive cancer may be found in up to 80% of the disappearing tumors after resection.
methodsRetrospective review of 14 patients who underwent LT for CRLM, at 2 centers. Radiographic and pathologic correlation of the number of tumors and their viability before and after LT was performed.
resultsThe median (interquartile range) number of tumors at diagnosis was 11 (4-23). The median number of chemotherapy cycles was 24 (16-37). Hepatic artery infusion was used in 5 patients (35.7%); 6 (42.9%) underwent surgical resection, and 5 (35.7%) received locoregional therapy. The indication for LT was unresectability in 8 patients (57.1%) and liver failure secondary to oncologic treatment in the remaining 6 (42.9%). Before LT, 7 patients (50%) demonstrated fluorodeoxyglucose-avid tumors and 7 (50%) had a complete radiographic response. Histopathologically, 11 patients (78.6%) had a viable tumor. Nine (64.2%) of the 14 patients were found to have undiagnosed metastases on explant pathology, with at least 22 unaccounted viable tumors before LT. Furthermore, 4 (57.1%) of the 7 patients who demonstrated complete radiographic response harbored viable carcinoma on explant pathology.
conclusionsA complete radiographic response does not reliably predict a complete pathologic response. In patients with unresectable CRLM, total hepatectomy and LT represent a promising treatment options to prevent indolent disease progression from disappearing CRLM.
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