ArticleThe Annals of otology, rhinology, and laryngology2023
The Detection of Bacteria in the Maxillary Sinus Secretion of Patients With Acute Rhinosinusitis Using an Electronic Nose: A Pilot Study.
Article in The Annals of otology, rhinology, and laryngology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07781215 (Stool Profile in Evaluating Colitis Treatment Response, Outcome and Severity), which is not on this map. Not yet cited in PubMed.
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Stool Profile in Evaluating Colitis Treatment Response, Outcome and Severity
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
objectiveDetecting bacteria as a causative pathogen of acute rhinosinusitis (ARS) is a challenging task. Electronic nose technology is a novel method for detecting volatile organic compounds (VOCs) that has also been studied in association with the detection of several diseases. The aim of this pilot study was to analyze maxillary sinus secretion with differential mobility spectrometry (DMS) and to determine whether the secretion demonstrates a different VOC profile when bacteria are present.
methodsAdult patients with ARS symptoms were examined. Maxillary sinus contents were aspirated for bacterial culture and DMS analysis.
resultsA total of 26 samples from 15 patients were obtained. After leave-one-out cross-validation,
conclusionsThe results of this pilot study suggest that bacterial positive and bacterial negative sinus secretion release different VOCs and that DMS has the potential to detect them. However, as the results are based on limited data, further conclusions cannot be made. DMS is a novel method in disease diagnostics and future studies should examine whether the method can detect bacterial ARS by analyzing exhaled air.
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