ArticleHuman brain mapping2023
Prenatal depressive symptoms and childhood development of brain limbic and default mode network structure.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Beyond Trauma Exposure and Symptoms: Preconception Transdiagnostic Vulnerability and Postpartum Outcomes in Healthy Women.Journal of clinical medicine · 2026Article
- A Longitudinal Study of Children's Hippocampal Development: Investigating Maternal Physical Activity, Depression, and Education.Developmental neurobiology · 2026Article
- The association between prenatal maternal anxiety, infant brain volumes, and temperament during the COVID-19 pandemic.Translational psychiatry · 2025Article
- Maternal depressive symptoms in childhood and offspring brain cortical and subcortical volumetric change: A repeated imaging study from age 4-10 years.Developmental cognitive neuroscience · 2025Article
- White matter structural changes before and after microvascular decompression for hemifacial spasm.Brain structure & function · 2024Article
- Prenatal depressive symptoms and childhood development of brain limbic and default mode network structure.Human brain mapping · 2023Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Prenatal depressive symptoms are linked to negative child behavioral and cognitive outcomes and predict later psychopathology in adolescent children. Prior work links prenatal depressive symptoms to child brain structure in regions like the amygdala; however, the relationship between symptoms and the development of brain structure over time remains unclear. We measured maternal depressive symptoms during pregnancy and acquired longitudinal T1-weighted and diffusion imaging data in children (n = 111; 60 females) between 2.6 and 8 years of age. Controlling for postnatal symptoms, we used linear mixed effects models to test relationships between prenatal depressive symptoms and age-related changes in (i) amygdala and hippocampal volume and (ii) structural properties of the limbic and default-mode networks using graph theory. Higher prenatal depressive symptoms in the second trimester were associated with more curvilinear trajectories of left amygdala volume changes. Higher prenatal depressive symptoms in the third trimester were associated with slower age-related changes in limbic global efficiency and average node degree across childhood. Our work provides evidence that moderate symptoms of prenatal depression in a low sociodemographic risk sample are associated with structural brain development in regions and networks implicated in emotion processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.