Evidence map›Paper›PMID 36691927›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and

Mohammad M Al-Sanea, Abdelrahman Hamdi, Ahmed A B Mohamed, Hamed W El-Shafey, Mahmoud Moustafa, Abdullah A Elgazar, Wagdy M Eldehna, Hidayat Ur Rahman, Della G T Parambi, Rehab M Elbargisy and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 44 citations in OpenAlex.

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  10. Design, synthesis, andRSC advances · 2024
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  14. Synthesis, cytotoxicity andFuture medicinal chemistry · 2024
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  15. Design, Synthesis, Pharmacological Evaluation of Quinazolin-4(3Drug design, development and therapy · 2024
    Article
  16. Review
  17. Identification of sulphonamide-tetheredJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
  18. Article
  19. Article
  20. Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis andSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Mohammad M Al-SaneaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Abdelrahman HamdiDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Ahmed A B MohamedDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Hamed W El-ShafeyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Mahmoud MoustafaDepartment of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Abdullah A ElgazarDepartment of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.ORCID 0000-0001-6996-4017
Hidayat Ur RahmanDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Della G T ParambiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.ORCID 0000-0002-3954-4879
Rehab M ElbargisyDepartment of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Samy SelimDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia.
Syed Nasir Abbas BukhariDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Omnia Magdy HendawyDepartment of Pharmacology, College of Pharmacy, Jouf University, Aljouf, Saudi Arabia.
Samar S TawfikDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Jouf University · SAMansoura University · EGKafrelsheikh University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new series of 2-aminobenzothiazole hybrids linked to thiazolidine-2,4-dione

Indexed as

Antineoplastic AgentsBenzothiazolesCell ProliferationDrug Screening Assays, AntitumorHumansMCF-7 CellsMolecular Docking SimulationMolecular StructureProtein Kinase InhibitorsSorafenibStructure-Activity RelationshipVascular Endothelial Growth Factor Receptor-2Antineoplastic AgentsBenzothiazolesKDR protein, humanProtein Kinase InhibitorsSorafenibVascular Endothelial Growth Factor Receptor-2134-thiadiazoles2-Aminobenzothiazolecyanothiouracilsthiazolidine-24-dionesVEGFR-2 inhibition

Identifiers

PMID36691927
PMCPMC9879182
OpenAlexW4317871089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.