Evidence map›Paper›PMID 36691656›Full record

ArticleACS environmental Au2023

Binding Between Antibiotics and Polystyrene Nanoparticles Examined by NMR.

Saduni S Arachchi, Stephanie P Palma, Charlotte I Sanders, Hui Xu, Rajshree Ghosh Biswas, Ronald Soong, André J Simpson, Leah B Casabianca

Open access · goldAbstract read
In one paragraph

Article in ACS environmental Au, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Saduni S ArachchiDepartment of Chemistry, Clemson University, Clemson, South Carolina29634, United States.
Stephanie P PalmaDepartment of Chemistry, Clemson University, Clemson, South Carolina29634, United States.
Charlotte I SandersDepartment of Chemistry, Clemson University, Clemson, South Carolina29634, United States.
Hui XuDepartment of Chemistry, Clemson University, Clemson, South Carolina29634, United States.
Rajshree Ghosh BiswasDepartment of Chemistry, University of Toronto Scarborough, Toronto, OntarioM1C 1A4, Canada.
Ronald SoongDepartment of Chemistry, University of Toronto Scarborough, Toronto, OntarioM1C 1A4, Canada.ORCID https://orcid.org/0000-0002-8223-9028
André J SimpsonDepartment of Chemistry, University of Toronto Scarborough, Toronto, OntarioM1C 1A4, Canada.ORCID https://orcid.org/0000-0002-8247-5450
Leah B CasabiancaDepartment of Chemistry, Clemson University, Clemson, South Carolina29634, United States.ORCID https://orcid.org/0000-0001-9447-3236
Clemson University · USUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elucidating the interactions between plastic nanoparticles and small molecules is important to understanding these interactions as they occur in polluted waterways. For example, plastic that breaks down into micro- and nanoscale particles will interact with small molecule pollutants that are also present in contaminated waters. Other components of natural water, such as dissolved organic matter, will also influence these interactions. Here we use a collection of complementary NMR techniques to examine the binding between polystyrene nanoparticles and three common antibiotics, belonging to a class of molecules that are expected to be common in polluted water. Through examination of proton NMR signal intensity, relaxation times, saturation-transfer difference (STD) NMR, and competition STD-NMR, we find that the antibiotics have binding strengths in the order amoxicillin < metronidazole ≪ levofloxacin. Levofloxacin is able to compete for binding sites, preventing the other two antibiotics from binding. The presence of tannic acid disrupts the binding between levofloxacin and the polystyrene nanoparticles, but does not influence the binding between metronidazole and these nanoparticles.

Identifiers

PMID36691656
PMCPMC9856636
OpenAlexW4307157184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.