Evidence map›Paper›PMID 36691606›Full record

ArticleMaterials today. Bio2023

Barrier-penetrating liposome targeted delivery of basic fibroblast growth factor for spinal cord injury repair.

Fenzan Wu, Penghui Wang, Xiaojie Wei, Yanhong Yang, Abdullah Al Mamun, Xie Zhang, Yunsen Zhu, Tingting Mo, Hongyu Zhang, Chang Jiang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Systematic Review of Peptide CAQK: Properties, Applications, and Outcomes.International journal of molecular sciences · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Fenzan WuDepartment of Arthroplasty, The First People's Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, Zhejiang, 317500, China.
Penghui WangTranslational Medicine Laboratory, Affiliated Cixi Hospital, Wenzhou Medical University, Zhejiang, 325300, China.
Xiaojie WeiTranslational Medicine Laboratory, Affiliated Cixi Hospital, Wenzhou Medical University, Zhejiang, 325300, China.
Yanhong YangSchool of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, 325035, China.
Abdullah Al MamunSchool of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, 325035, China.
Xie ZhangDepartment of Pharmacy, Ningbo Medical Treatment Center Li Huili Hospital, Zhejiang, 315040, China.
Yunsen ZhuDepartment of Arthroplasty, The First People's Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, Zhejiang, 317500, China.
Tingting MoDepartment of Arthroplasty, The First People's Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, Zhejiang, 317500, China.
Hongyu ZhangDepartment of Arthroplasty, The First People's Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, Zhejiang, 317500, China.
Chang JiangDepartment of Arthroplasty, The First People's Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, Zhejiang, 317500, China.
Jie HuStem Cell Translation Laboratory, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Shanxi, 030032, China.
Jian XiaoDepartment of Arthroplasty, The First People's Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, Zhejiang, 317500, China.
Wenzhou Medical University · CNNingbo Medical Center Lihuili Hospital · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticle technologies offer a non-invasive means to deliver basic fibroblast growth factor (bFGF) for the treatment of spinal cord injury (SCI). However, the inability of bFGF to accumulate at the injury site and inefficient penetration across the blood-spinal cord barrier (BSCB) remain challenges. The present study describes a dual-targeting liposome (bFGF@Lip-Cp&Rp) with injury lesion targeting and BSCB-penetrating capability to deliver bFGF for SCI treatment. The CAQK peptide (Cp) with injury lesion targeting ability and R

Indexed as

1H NMR, 1H Nuclear magnetic resonanceArg-1, Arginase 1Basic fibroblast growth factorBBB, Basso-Beattie-BresnahanbFGF, Basic fibroblast growth factorBSCB, Blood-spinal cord barrierCCK-8, Cell counting kit-8CD31, Platelet endothelial cell adhesion molecule-1CD86, Cluster of differentiation 86Cp, CAQK peptideCSPGs, Chondroitin sulfate proteoglycansDiI, 1-dioctadecyl-3,3,3,3-tetramethylindocarbocyanine perchlorateDrug deliveryDSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]FITC-BSA, Fluorescein isothiocyanate-labeled bovine serum albuminGFAP, Glial fibrillary acidic proteinHUVECs, Human umbilical vein endothelial cellsIL-10, Interleukin 10LiposomeMal, MaleimideNF-200, Neurofilament-200NGF, Nerve growth factorNT-3, Neurotrophin-3Rp, R2KC peptideSCI, Spinal cord injurySpinal cord injuryTargetTGF-β, Transforming growth factor-βVEGF-A, Vascular endothelial growth factor AZO-1, Zonulaoccludens 1

Identifiers

PMID36691606
PMCPMC9860515
OpenAlexW4313680775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.