Evidence map›Paper›PMID 36691521›Full record

ArticleBiofilm2023

Dissolvable alginate hydrogel-based biofilm microreactors for antibiotic susceptibility assays.

Le Hoang Phu Pham, Khanh Loan Ly, Mariliz Colon-Ascanio, Jin Ou, Hao Wang, Sang Won Lee, Yi Wang, John S Choy, Kenneth Scott Phillips, Xiaolong Luo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biofilm, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Le Hoang Phu PhamDepartment of Mechanical Engineering, The Catholic University of America, Washington, DC, 20064, USA.
Khanh Loan LyDepartment of Biomedical Engineering, The Catholic University of America, Washington, DC, 20064, USA.
Mariliz Colon-AscanioDepartment of Biology, The Catholic University of America, Washington, DC, 20064, USA.
Jin OuDepartment of Biology, The Catholic University of America, Washington, DC, 20064, USA.
Hao WangDivision of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, White Oak, MD, 20993, USA.
Sang Won LeeDivision of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, White Oak, MD, 20993, USA.
Yi WangDivision of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, White Oak, MD, 20993, USA.
John S ChoyDepartment of Biology, The Catholic University of America, Washington, DC, 20064, USA.
Kenneth Scott PhillipsDivision of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, White Oak, MD, 20993, USA.
Xiaolong LuoDepartment of Mechanical Engineering, The Catholic University of America, Washington, DC, 20064, USA.
University of America · USUnited States Food and Drug Administration · US

Funding

Heterogeneous synthetic microbiome constructed with biopolymer fluitrodesR15GM129766 · NIGMS · CATHOLIC UNIVERSITY OF AMERICA · PI CHOY, JOHN SING, LUO, XIAOLONG · 2018 to 2018
$465k
NIGMS NIH HHS R15 GM129766
6 · The paper itself

Abstract

Biofilms are found in many infections in the forms of surface-adhering aggregates on medical devices, small clumps in tissues, or even in synovial fluid. Although antibiotic resistance genes are studied and monitored in the clinic, the structural and phenotypic changes that take place in biofilms can also lead to significant changes in how bacteria respond to antibiotics. Therefore, it is important to better understand the relationship between biofilm phenotypes and resistance and develop approaches that are compatible with clinical testing. Current methods for studying antimicrobial susceptibility are mostly planktonic or planar biofilm reactors. In this work, we develop a new type of biofilm reactor-three-dimensional (3D) microreactors-to recreate biofilms in a microenvironment that better mimics those

Indexed as

Antibiotic resistanceAntibiotic susceptibility assaysBiofilm microreactorsBiofilm phenotypeHydrogel

Identifiers

PMID36691521
PMCPMC9860113
OpenAlexW4313837194

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.