Evidence map›Paper›PMID 36691248›Full record

Trial reportBMJ open2022

Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice.

Marta Wanat, Marta Santillo, Ushma Galal, Mina Davoudianfar, Emily Bongard, Sinisa Savic, Louise Savic, Catherine Porter, Joanne Fielding, Christopher C Butler and 4 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04108637 (Penicillin Allergy Status And Its Effect On Antibiotic Prescribing, Patient Outcomes, and Antimicrobial Resistance), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04108637 nacompletednot on this map

Penicillin Allergy Status And Its Effect On Antibiotic Prescribing, Patient Outcomes, and Antimicrobial Resistance

TypeinterventionalSponsorUniversity of LeedsRan2019 to 2024Enrolled823ConditionsInfectionArmspenicillin allergy assessment pathway
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Marta WanatNuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK marta.wanat@phc.ox.ac.uk.ORCID 0000-0002-0163-1547
Marta SantilloNuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK.ORCID 0000-0001-6345-7612
Ushma GalalNuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK.
Mina DavoudianfarNuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK.
Emily BongardNuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK.ORCID 0000-0001-5957-6280
Sinisa SavicUniversity of Leeds and Leeds Teaching Hospitals NHS Trust, Faculty of Medicine and Health, Leeds, UK.ORCID 0000-0001-7910-0554
Louise SavicUniversity of Leeds and Leeds Teaching Hospitals NHS Trust, Faculty of Medicine and Health, Leeds, UK.
Catherine PorterHealthcare Associated Infection Group, University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Joanne FieldingHealthcare Associated Infection Group, University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Christopher C ButlerNuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK.ORCID 0000-0002-0102-3453
Sue PavittDental Translational and Clinical Research Unit, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Jonathan SandoeHealthcare Associated Infection Group, University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Sarah Tonkin-CrineNuffield Department of Primary Care Health Sciences, Oxford University, Oxford, UK.ORCID 0000-0003-4470-1151
ALABAMA team
University of Leeds · GBUniversity of Oxford · GBNational Institute for Health Research · GB

Funding

Department of Health NIHR200915Department of Health RP-PG-1214-20007
6 · The paper itself

Abstract

objectivesAbout 6% of the UK general practice population has a record of a penicillin allergy but fewer than 10% of these are likely to be truly allergic. In the ALABAMA (Allergy Antibiotics and Microbial resistance) feasibility trial, primary care patients with penicillin allergy were randomised to penicillin allergy assessment pathway or usual care to assess the effect on health outcomes. A behavioural intervention package was developed to aid delabelling. This study aimed to investigate patients' and clinicians' views of penicillin allergy testing (PAT).

designWe conducted a mixed-methods process evaluation embedded within the ALABAMA trial, which included a clinician survey, a patient survey (at baseline and follow-up) and semistructured interviews with patients and clinicians. SETTINGS: The study was conducted in primary care, as part of the feasibility stage of the ALABAMA trial.

participantsPatients and primary care clinicians.

resultsClinicians (N=53; 52.2%) were positive about PAT and its potential value but did not have previous experience of referring patients for a PAT and were unsure whether patients would take penicillin after a negative allergy test. Patients (N=36; 46%) were unsure whether they were severely allergic to penicillin and did not fear a severe allergic reaction to penicillin. Clinician interviews showed that they were already aware of the benefit of PAT. Interviews with patients suggested the importance of safety as patients valued having numerous opportunities to address their concerns about safety of the test.

conclusionsThis study highlights the positive effects of the ALABAMA behavioural intervention for both patients and clinicians. TRIAL REGISTRATION NUMBER: NCT04108637; ISRCTN20579216; Pre-results.

Indexed as

Drug HypersensitivityGeneral PracticeHypersensitivityAnti-Bacterial AgentsBehavior TherapyHumansPenicillinsUnited KingdomAnti-Bacterial AgentsPenicillinsimmunologyprimary carequalitative research

Identifiers

PMID36691248
PMCPMC9171226
OpenAlexW4281982035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.