Evidence map›Paper›PMID 36691196›Full record

ArticleBMJ open2022

Adapting the FAST-M maternal sepsis intervention for implementation in Pakistan: a qualitative exploratory study.

Sheikh Irfan Ahmed, Bakhtawar M Hanif Khowaja, Rubina Barolia, Raheel Sikandar, Ghulam Kubra Rind, Sehrish Khan, Raheela Rani, James Cheshire, Catherine Louise Dunlop, Arri Coomarasamy and 2 more

Abstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. The FemTech revolution: Unlocking the potential of new technology for optimizing pregnancy outcomes in low- and middle-income countries and remote areas.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sheikh Irfan AhmedObstetrics and Gynecology, The Aga Khan University, Karachi, Pakistan sheikh.irfan@aku.edu.ORCID 0000-0002-8391-8559
Bakhtawar M Hanif KhowajaObstetrics and Gynecology, The Aga Khan University, Karachi, Pakistan.
Rubina BaroliaSchool of Nursing and Midwifery, Aga Khan University, Karachi, Pakistan.
Raheel SikandarObstetrics and Gynecology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Ghulam Kubra RindObstetrics and Gynecology, The Aga Khan University, Karachi, Pakistan.
Sehrish KhanObstetrics and Gynecology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Raheela RaniObstetrics and Gynecology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
James CheshireInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Catherine Louise DunlopInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-4792-9496
Arri CoomarasamyInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Lumaan SheikhObstetric & Gynecology, The Aga Khan University Hospital, Karachi, Pakistan.
David LissauerInstitute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Funding

Department of Health NIHR300808Medical Research Council MR/K007408/1
6 · The paper itself

Abstract

objectiveA maternal sepsis management bundle for resource-limited settings was developed through a synthesis of evidence and international consensus. This bundle, called 'FAST-M' consists of: Fluids, Antibiotics, Source control, assessment of the need to Transport/Transfer to a higher level of care and ongoing Monitoring (of the mother and neonate). The study aimed to adapt the FAST-M intervention including the bundle care tools for early identification and management of maternal sepsis in a low-resource setting of Pakistan and identify potential facilitators and barriers to its implementation.

settingThe study was conducted at the Liaquat University of Medical and Health Sciences, which is a tertiary referral public sector hospital in Hyderabad. DESIGN AND

participantsA qualitative exploratory study comprising key informant interviews and a focus group discussion was conducted with healthcare providers (HCPs) working in the study setting between November 2020 and January 2021, to ascertain the potential facilitators and barriers to the implementation of the FAST-M intervention. Interview guides were developed using the five domains of the Consolidated Framework for Implementation Research: intervention characteristics, outer setting, inner setting, characteristics of the individuals and process of implementation.

resultsFour overarching themes were identified, the hindering factors for implementation of the FAST-M intervention were: (1) Challenges in existing system such as a shortage of resources and lack of quality assurance; and (2) Clinical practice variation that includes lack of sepsis guidelines and documentation; the facilitating factors identified were: (3) HCPs' perceptions about the FAST-M intervention and their positive views about its execution and (4) Development of HCPs readiness for FAST-M implementation that aided in identifying solutions to potential hindering factors at their clinical setting.

conclusionThe study has identified potential gaps and probable solutions to the implementation of the FAST-M intervention, with modifications for adaptation in the local context TRIAL REGISTRATION NUMBER: ISRCTN17105658.

Indexed as

Health PersonnelPregnancy Complications, InfectiousFemaleFocus GroupsHumansInfant, NewbornPakistanPregnancyQualitative Researchhealth & safetyinfectious diseasesobstetricspublic healthreproductive medicine

Identifiers

PMID36691196
PMCPMC9472171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.