Evidence map›Paper›PMID 36691076›Full record

ArticleActa neuropathologica communications2023

Parkin coregulates glutathione metabolism in adult mammalian brain.

Daniel N El Kodsi, Jacqueline M Tokarew, Rajib Sengupta, Nathalie A Lengacher, Ajanta Chatterji, Angela P Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 4 countries.

Daniel N El Kodsi *Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Jacqueline M Tokarew *Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Rajib SenguptaDepartment of Biochemistry, Karolinska Institute, Stockholm, Sweden.
Nathalie A LengacherProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ajanta ChatterjiProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Angela P NguyenProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Heather BostonProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Qiubo JiangProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Carina PalmbergDepartment of Biochemistry, Karolinska Institute, Stockholm, Sweden.
Chantal PileggiDepartment of Biochemistry, Microbiology and Immunology Faculty of Medicine, and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.
Chet E HoltermanKidney Research Center, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Bojan ShutinoskiProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Juan LiProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Travis K FehrProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Matthew J LaVoieDepartment of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Rajiv R RatanBurke Neurological Institute, Weill Cornell Medical School, White Plains, NY, USA.
Gary S ShawDepartment of Biochemistry, University of Western Ontario, London, ON, Canada.
Masashi TakanashiDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Christopher R KennedyKidney Research Center, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Mary-Ellen HarperDepartment of Biochemistry, Microbiology and Immunology Faculty of Medicine, and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.
Arne HolmgrenDepartment of Biochemistry, Karolinska Institute, Stockholm, Sweden.
Julianna J TomlinsonProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada. jtomlinson@ohri.ca.
Michael G SchlossmacherProgram in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON, Canada. mschlossmacher@toh.ca.ORCID 0000-0002-0394-0300
University of Ottawa · CAOttawa Hospital · CAKarolinska Institutet · SEJuntendo University · JPCornell University · USUniversity of Calgary · CAUniversity of Florida · USWestern University · CA

Funding

Role of Parkin in Familial and Idiopathic Parkinson's DiseaseR01NS065013 · NINDS · UNIVERSITY OF FLORIDA · PI LAVOIE, MATTHEW J · 2010 to 2020
$3.8M
NIH HHS R01NS065013NINDS NIH HHS R01 NS065013
6 · The paper itself

Abstract

We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adult prkn

Indexed as

GlutathioneProteinsAdultAnimalsAntioxidantsBrainCysteineGlutathione DisulfideHumansMammalsMiceOxidation-ReductionOxidative StressSulfhydryl CompoundsUbiquitin-Protein LigasesAntioxidantsCysteineGlutathioneGlutathione DisulfideProteinsSulfhydryl CompoundsUbiquitin-Protein LigasesEarly-onset Parkinson diseaseGlutathione metabolismMass spectrometryParkinPosttranslational modificationPrknRedox stressSod2

Identifiers

PMID36691076
PMCPMC9869535
OpenAlexW4317721991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.