Evidence map›Paper›PMID 36691023›Full record

ArticleCost effectiveness and resource allocation : C/E2023

Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis.

Anna-Janina Stephan, Marion de Lepper, Regine Wölle, Agnes Luzak, Wei Wang, Christian Jacob, Kim Maren Schneider, Horst Buxmann, Rangmar Goelz, Klaus Hamprecht and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cost effectiveness and resource allocation : C/E, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Anna-Janina Stephan *Department of Market Access, MSD Sharp & Dohme GmbH, Munich, Germany.
Marion de Lepper *Department of Medical Affairs, MSD Sharp & Dohme GmbH, Munich, Germany. marion.de.lepper@msd.de.
Regine WölleDepartment of Market Access, MSD Sharp & Dohme GmbH, Munich, Germany.
Agnes LuzakDepartment of Market Access, MSD Sharp & Dohme GmbH, Munich, Germany.
Wei WangCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, NJ, USA.
Christian JacobEU Real World Evidence, Xcenda GmbH, Hannover, Germany.
Kim Maren SchneiderEU Real World Evidence, Xcenda GmbH, Hannover, Germany.
Horst BuxmannDepartment for Children and Adolescents, Division for Neonatology, Main-Kinzig-Kliniken GmbH, Gelnhausen, Germany.
Rangmar GoelzDepartment of Neonatology, University Children's Hospital, Tuebingen, Germany.
Klaus HamprechtInstitute for Medical Virology and Epidemiology of Viral Diseases, University of Tuebingen, Tuebingen, Germany.
Peter KummerSection of Phoniatrics and Pediatric Audiology, Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany.
Susanne ModrowInstitute of Medical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.
Wolfgang GreinerDepartment of Health Economics and Health Care Management, Bielefeld School of Public Health, Bielefeld University, Bielefeld, Germany.
Miriam ReuschenbachGlobal Medical and Scientific Affairs, MSD Sharp & Dohme GmbH, Munich, Germany.
MSD (Germany) · DEUniversity Hospital Regensburg · DEBielefeld University · DEMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity Children's Hospital Tübingen · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life.

methodsWe conducted a retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database. Incremental healthcare costs during the first and second year of life were assessed by matching (1:60) infants with cCMV diagnoses ≤ 90 days after birth (cCMV

resultsWe identified 54 and 24 infants born 2014-2018 for the cCMV

conclusionscCMV comprises a considerable economic burden for the German healthcare system (€19,646 to €33,818 higher mean costs for infants with recorded cCMV diagnosis in the first year of life). Attempts should be made to reduce this burden.

Indexed as

Administrative dataCongenital CMV infectionGermanyHealth economic burdenNewborns

Identifiers

PMID36691023
PMCPMC9872342
OpenAlexW4317751897

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.