Evidence map›Paper›PMID 36691016›Full record

ArticleBMC endocrine disorders2023

Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism.

Wenxian Xu, Yizhou Huang, Linjuan Ma, Peiqiong Chen, Saisai Li, Ketan Chu, Yibing Lan, Chunming Li, Yang Song, Qian Ying and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Wenxian XuDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Yizhou HuangDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Linjuan MaDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Peiqiong ChenDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Saisai LiDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Ketan ChuDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Yibing LanDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Chunming LiDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Yang SongDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China.
Qian YingZhejiang Cancer Hospital, 310022, Hangzhou, People's Republic of China.
Jianhong ZhouDepartment of Gynecology Women's Hospital School of Medicine, Zhejiang University, First Xueshi Rd, 310006, Hangzhou, People's Republic of China. zhoujh1117@zju.edu.cn.
Women's Hospital, School of Medicine, Zhejiang University · CNZhejiang Cancer Hospital · CN

Funding

National Natural Science Foundation of China 81873810National Natural Science Foundation of China 82001463National Natural Science Foundation of China 82003469
6 · The paper itself

Abstract

backgroundTo evaluate the endocrine hormone and metabolic indices in postmenopausal women with euthyroid and mild subclinical hypothyroidism after menopause hormone therapy (MHT).

methodsA retrospective study of 587 postmenopausal women receiving MHT was conducted. Median (25-75th percentile) age was 52 (49-54) years. According to thyroid stimulating hormone (TSH) levels at initial diagnosis, the patients were divided into three groups: I (euthyroid with low normal TSH range, n = 460), II (euthyroid with upper normal TSH range, n = 106) and III (mild subclinical hypothyroidism, n = 21). After a continuous oral MHT regimen using the same estradiol potency for 6-18 month cycles, serum endocrine hormone and metabolic indices were reassessed.

resultsCompared with baseline, serum TSH levels in groups I and II significantly changed but all values were within the normal range. No significant difference was observed in serum TSH levels in group III. After treatment, all serum free tri-iodothyronine and free thyroxine levels were within the normal range. Serum total cholesterol, triglyceride, fasting plasma glucose, fasting insulin levels and homeostasis model assessment of insulin resistance index had significantly decreased in group I. There were no significant differences in all observed lipid and glucose parameters in group III, before and after treatment.

conclusionMHT did not affect thyroid function in postmenopausal women with euthyroid and mild subclinical hypothyroidism. MHT led to an improvement in lipid and glucose indicators in euthyroid women with low normal TSH range.

Indexed as

HypothyroidismThyrotropinFemaleGlucoseHormone Replacement TherapyHumansMiddle AgedPostmenopauseRetrospective StudiesThyroxineTriglyceridesGlucoseThyrotropinThyroxineTriglyceridesGlucose and lipid metabolismMenopause hormone therapyMild subclinical hypothyroidismPostmenopausal womenThyroid stimulating hormone

Identifiers

PMID36691016
PMCPMC9869540
OpenAlexW4317746118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.