ArticleNature neuroscience2023
Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 61 citations in OpenAlex.
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- A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.bioRxiv : the preprint server for biology · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Enhanced reward coding and condition-independent dynamics in optogenetically identified corticostriatal neurons in monkeys.Nature communications · 2026Article
- Neurons embedded in loop-like motifs act as central hubs for brain-wide integration.The Journal of physiology · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Distinct roles of cortical layer 5 subtypes in associative learning.Nature communications · 2026Article
- An intralayer microcircuit in the temporal association cortex underlies sensory-induced escape in mice.Nature communications · 2026Article
- Corticothalamic communication for action coordination in a skilled motor behavior.Nature neuroscience · 2026Article
- Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions.Nature neuroscience · 2026Article
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- From mice to clinical relevance: humanizing neuroscience with human-based model systems.Frontiers in cellular neuroscience · 2026Review
- Parietal cortex is causally required for state-dependent decisions.Cell reports · 2025Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across pyramidal neuron (PyN) types have been observed within cortical areas, but it is not known whether these local differences extend throughout the cortex, nor whether additional differences emerge when larger-scale dynamics are considered. We used genetic and retrograde labeling to target pyramidal tract, intratelencephalic and corticostriatal projection neurons and measured their cortex-wide activity. Each PyN type drove unique neural dynamics, both at the local and cortex-wide scales. Cortical activity and optogenetic inactivation during an auditory decision task revealed distinct functional roles. All PyNs in parietal cortex were recruited during perception of the auditory stimulus, but, surprisingly, pyramidal tract neurons had the largest causal role. In frontal cortex, all PyNs were required for accurate choices but showed distinct choice tuning. Our results reveal that rich, cell-type-specific cortical dynamics shape perceptual decisions.
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