ArticleNature cancer2023
Fucosylation of HLA-DRB1 regulates CD4
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Article in Nature cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling.Nature medicine · 2026Article
- L-Fucose: a dietary sugar with multifaceted potential in the biology and therapy of cancer.Nature reviews. Cancer · 2026Review
- Molecular profiling of breast cancer in native American women reveals distinct genomic and transcriptomic features.NPJ precision oncology · 2026Article
- Differentiated Thyroid Cancer Is Associated With Sex-specific Immune Response.Journal of the Endocrine Society · 2026Article
- Clinical Significance of RBM15 in Gastric Cancer: A Multi-Database Validation.Current medicinal chemistry · 2026Article
- Perioperative Profiles of Immune Cells in Patients with Postoperative Delirium After Cardiac Surgery with Cardiopulmonary Bypass.Biomedicines · 2025Article
- C-6-Modified 2-F-Fucose Derivatives as Inhibitors of Fucosyltransferases.Chembiochem : a European journal of chemical biology · 2025Article
- Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation.Genes & diseases · 2025Review
- N-glycans in lung tissue specimens: a prospective target for enhanced cancer diagnosis and prognosis.Journal of translational medicine · 2025Article
- Repurposing CDP-Tyvelose 2‑Epimerase Enables a GDP-Fucose-Based Fucosylation Pathway Starting from Sucrose.JACS Au · 2025Article
- Tumor Glycosylation: A Main Player in the Modulation of Immune Responses.European journal of immunology · 2025Review
- Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis.Frontiers in molecular biosciences · 2025Article
- A Novel KIF4A-related Model for Predicting Immunotherapy Response and Prognosis in Kidney Renal Clear Cell Carcinoma.Combinatorial chemistry & high throughput screening · 2025Article
- Molecular mechanism of enhancing antitumor activity through the interaction between monosaccharides and human serum albumin.Analytical and bioanalytical chemistry · 2025Article
- Proteomic Profiling of Serum-Derived Exosomes in Oral Lichen Planus: FN1-C3-ECM Crosstalk as a Potential Novel Therapeutic Target.Journal of inflammation research · 2025Article
- Prognostic significance of B cell senescence-associated genes as risk markers in prostate adenocarcinoma.Translational cancer research · 2024Article
- Hepatocellular carcinoma-specific epigenetic checkpoints bidirectionally regulate the antitumor immunity of CD4 + T cells.Cellular & molecular immunology · 2024Article
- Tumor Biology Hides Novel Therapeutic Approaches to Diffuse Large B-Cell Lymphoma: A Narrative Review.International journal of molecular sciences · 2024Review
- Whole Exome Sequencing of Intracranial Epidermoid Cysts Reveals Immune-Associated Mechanistic and Potential Targets.Cancers · 2024Article
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Authors and funding
36 authors at 6 institutions in 1 country.
Daniel K LesterDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Chase BurtonDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Alycia GardnerCancer Biology Ph.D. Program, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-2185-5174
Patrick InnamaratoCancer Biology Ph.D. Program, University of South Florida, Tampa, FL, USA.
Krithika KodumudiDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Qian LiuDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Emma AdhikariDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Qianqian MingMolecular Medicine Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Daniel B WilliamsonComplex Carbohydrate Research Center, the University of Georgia, Athens, GA, USA.
Dennie T FrederickDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3355-5267
Tatyana SharovaDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Michael G WhiteDepartment of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5022-5505
Joseph MarkowitzImmunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Biwei CaoDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Jonathan NguyenAdvanced Analytical and Digital Laboratory, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-6146-2047
Joseph JohnsonDepartment of Analytic Microscopy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Matthew BeattyDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Andrea Mockabee-MaciasDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Matthew MercurioDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Gregory WatsonDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Pei-Ling ChenDepartment of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Susan McCarthyAdvanced Analytical and Digital Laboratory, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Carlos MoranSeguraAdvanced Analytical and Digital Laboratory, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-8702-0554
Jane MessinaDepartment of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Kerry L ThomasDepartment of Diagnostic Imaging, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Lancia DarvilleProteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Victoria IzumiProteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
John M KoomenProteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-3818-1762
Shari A Pilon-ThomasDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Brian RuffellDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-3846-6872
Vincent C LucaMolecular Medicine Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Robert S HaltiwangerComplex Carbohydrate Research Center, the University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0001-7439-9577
Xuefeng WangDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-5775-408X
Jennifer A WargoDepartment of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-3438-7576
Genevieve M BolandDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7522-6173
Eric K LauDepartment of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. eric.lau@moffitt.org.ORCID http://orcid.org/0000-0003-3005-3421
Moffitt Cancer Center · USUniversity of South Florida · USMassachusetts General Hospital · USThe University of Texas MD Anderson Cancer Center · USUniversity of Georgia · USBroad Institute · US
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MO-Glycosylation of Epidermal Growth Factor-like MotifsR01GM061126 · NIGMS · UNIVERSITY OF GEORGIA · PI HALTIWANGER, ROBERT S. · 2001 to 2021
$9.1MEnhancing TIL populations and immunotherapy efficacy in melanoma by modulating fucosylationR01CA241559 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI LAU, ERIC KIRK · 2019 to 2023
$2.1MThe PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanomaR00CA172705 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI LAU, ERIC KIRK · 2015 to 2017
$735kNitric oxide immune dependent resistance mechanisms to anti-PD-1 therapyK08CA252164 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI MARKOWITZ, JOSEPH · 2021 to 2023
$707kThe PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanomaK99CA172705 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI LAU, ERIC KIRK · 2013 to 2014
$216kNCI NIH HHS K08 CA252164NCI NIH HHS K99 CA172705NCI NIH HHS P30 CA076292NCI NIH HHS R00 CA172705NCI NIH HHS R01 CA241559NIGMS NIH HHS R01 GM061126
Abstract
Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immune cells (itICs); thus, effective strategies to safely increase itICs are needed. We report that dietary administration of L-fucose induces fucosylation and cell surface enrichment of the major histocompatibility complex (MHC)-II protein HLA-DRB1 in melanoma cells, triggering CD4
Indexed as
FucoseMelanomaCD4-Positive T-LymphocytesHLA-DRB1 ChainsHumansImmunotherapyFucoseHLA-DRB1 Chains
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