Evidence map›Paper›PMID 36690807›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2023

Glycemia is associated with subclinical atherosclerosis through renal function in nondiabetic apparently healthy adults: a mediation analysis.

Dimitrios Delialis, Evdokia Euthymiou, Georgios Georgiopoulos, Stavros Athanasopoulos, Georgios Mavraganis, Lasthenis Angelidakis, Ioannis Petropoulos, Dimitrios Bampatsias, Eleni Maneta, Raphael Patras and 5 more

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Dimitrios Delialis *Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Evdokia Euthymiou *Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Georgios Georgiopoulos *Department of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Stavros AthanasopoulosDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Georgios MavraganisDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Lasthenis AngelidakisDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Ioannis PetropoulosDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Dimitrios BampatsiasDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Eleni ManetaDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Raphael PatrasDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Christina KonstantakiDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Maria PapaioannouDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Georgia KotsiraDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Asimina MitrakouDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Kimon StamatelopoulosDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens Medical School, Athens, Greece. kstamatel@med.uoa.gr.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causative associations between glycemia and early alterations in renal and vascular function remain unclear. To examine the interplay among glycemia, renal function, and markers of subclinical atherosclerosis in apparently healthy subjects. Nondiabetic (30-60 years old) individuals (n = 205) without chronic kidney disease or cardiovascular disease were consecutively recruited from a cardiovascular prevention clinic. All subjects underwent arterial stiffness assessment by measuring the carotid-femoral pulse wave velocity (cfPWV). Glomerular filtration rate (GFR) was estimated by CKD-EPI equation. Study procedures were identical in the two visits (median follow-up 66 months). We employed structural equation modeling (SEM) analysis to investigate the directionality of associations. Baseline fasting plasma glucose (FPG) was independently and inversely associated with GFR (p = 0.008). GFR was significantly associated with cfPWV (p < 0.001) at baseline. By SEM analysis decreasing baseline GFR directly correlated with increasing cfPWV (p = 0.003) whereas FPG correlated with cfPWV indirectly through GFR (mediation) (P = 0.032). FPG did not mediate the effect of GFR on cfPWV (P = 0.768). SEM analysis of longitudinal data revealed bidirectional correlations between changes in FPG and GFR (P < 0.001). Alterations in GFR were directly related to changes in cfPWV (p < 0.001) whereas FPG only indirectly correlated with cfPWV through GFR changes (P = 0.002). In apparently healthy nondiabetic subjects, the association between baseline or longitudinal glycemia levels and arterial stiffening was indirect, consistently mediated by renal function status. These findings provide the first clinical evidence supporting the directionality between kidney function and glycemia in nondiabetic subjects leading to vascular dysfunction. In apparently healthy nondiabetic subjects, without cardiovascular disease or chronic kidney disease, the association between baseline or longitudinal glycemia levels and arterial stiffening was indirect, consistently mediated by renal function status.

Indexed as

AtherosclerosisCardiovascular DiseasesRenal Insufficiency, ChronicVascular StiffnessAdultBlood PressureHumansKidneyMediation AnalysisMiddle AgedPulse Wave AnalysisRisk FactorsArterial stiffnessGlycemiaPulse wave velocityRenal functionSubclinical atherosclerosis

Identifiers

PMID36690807
OpenAlexW4317743672

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.