Evidence map›Paper›PMID 36690793›Full record

ReviewMolecular psychiatry2023

Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment.

Robert A McCutcheon, Richard S E Keefe, Philip K McGuire

Erratum issued Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07702526 (Effects of an Eye-Movement Intervention on Cognitive Impairment in Individuals Across Illness Stages of Schizophrenia), which is not on this map. Cited by 412 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
412citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07702526 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of an Eye-Movement Intervention on Cognitive Impairment in Individuals Across Illness Stages of Schizophrenia: Protocol for a Stratified Randomized, Active-Controlled, Assessor-Blinded Trial

TypeinterventionalSponsorShanghai Mental Health CenterRan2026 to 2028Enrolled160ConditionsSchizophrenia, Cognitive Impairment, Clinical High Risk for PsychosisArmsEye-Movement Training, Finger-Controlled Game Training
3 · Its place in the literature

Who cites it

412 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  2. Serotonin type 3 receptor (5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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352 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Robert A McCutcheonDepartment of Psychiatry, University of Oxford, Oxford, UK. Robert.mccutcheon@psych.ox.ac.uk.ORCID 0000-0003-1102-2566
Richard S E KeefeDepartments of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-0173-8897
Philip K McGuireDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0003-4381-0532

Funding

Wellcome Trust
6 · The paper itself

Abstract

Cognitive deficits are a core feature of schizophrenia, account for much of the impaired functioning associated with the disorder and are not responsive to existing treatments. In this review, we first describe the clinical presentation and natural history of these deficits. We then consider aetiological factors, highlighting how a range of similar genetic and environmental factors are associated with both cognitive function and schizophrenia. We then review the pathophysiological mechanisms thought to underlie cognitive symptoms, including the role of dopamine, cholinergic signalling and the balance between GABAergic interneurons and glutamatergic pyramidal cells. Finally, we review the clinical management of cognitive impairments and candidate novel treatments.

Indexed as

Cognition DisordersCognitive DysfunctionSchizophreniaCognitionHumansInterneurons

Identifiers

PMID36690793
PMCPMC10575791

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.