ArticleEuropean journal of clinical nutrition2023
Association of common genetic variants with body mass index in Russian population.
Article in European journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 0 citations in OpenAlex.
- Machine learning prediction of hypertension integrating polygenic risk scores in inner Eurasian populations.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
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Abstract
backgroundOverweight is the scourge of modern society and a major risk factor for many diseases. For this reason, understanding the genetic component predisposing to high body mass index (BMI) seems to be an important task along with preventive measures aimed at improving eating behavior and increasing physical activity.
methodsWe analyzed genetic data of a European cohort (n = 21,080, 47.25% women, East Slavs ancestry >80%) for 5 frequently found genes in the context of association with obesity: IPX3 (rs3751723), MC4R (rs17782313), TMEM18 (rs6548238), PPARG (rs1801282) and FTO (rs9939609).
resultsOur study revealed significant associations of FTO (rs9939609) (β = 0.37 (kg/m
conclusionsThe results confirm the contribution of FTO, M4CR, and TMEM18 genes to the mechanism of body weight regulation and control.
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