ArticleInsights into imaging2023
Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study.
Article in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Meta-analysis of resting-state fMRI in cervical spondylosis patients using AES-SDM.Frontiers in neurology · 2024Pooled it
- Brain MRI changes in degenerative cervical myelopathy: a systematic review.EBioMedicine · 2024Pooled it
- Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Designing machine learning-based models to predict residual pain after functional treatment of acute lateral ankle ligamentous sprains.Journal of orthopaedic surgery and research · 2026Article
- Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study.Frontiers in immunology · 2026Article
- Article
- Neural correlates of postoperative pain in patients with rotator cuff tear following arthroscopic surgery: a resting-state fMRI study.Scientific reports · 2025Article
- Inflammation-mediated regional brain alterations associated with mild cognitive impairment in knee osteoarthritis.Arthritis research & therapy · 2025Article
- A stacking ensemble machine learning model for predicting postoperative axial pain intensity in patients with degenerative cervical myelopathy.Scientific reports · 2025Article
- Neural correlates of central pain sensitization in chronic low back pain: a resting-state fMRI study.Neuroradiology · 2023Article
- Deficits in the thalamocortical pathway associated with hypersensitivity to pain in patients with frozen shoulder.Frontiers in neurology · 2023Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo test whether preoperative pain sensitivity is associated with the postoperative axial pain (PAP) in degenerative cervical myelopathy (DCM) and to explore its underlying brain mechanism.
methodsClinical data and resting-state fMRI data of 62 DCM patients along with 60 age/gender matched healthy participants were collected and analysed. Voxel-wise amplitude of low frequency fluctuation (ALFF) was computed and compared between DCM patients and healthy controls. Correlation analyses were performed to reveal the association between the clinical metrics and brain alterations. Clinical data and ALFF were also compared between DCM patients with PAP and without PAP.
results(1) Relative to healthy participants, DCM patients exhibited significantly lower preoperative pain threshold which is associated with the PAP intensity; (2) Relative to patients without PAP, PAP patients exhibited increased ALFF in mid-cingulate cortex (MCC) and lower preoperative pain threshold; (3) Further, multivariate pattern analysis revealed that MCC ALFF provide additional value for PAP vs. non-PAP classification.
conclusionIn conclusion, our findings suggest that preoperative pain hypersensitivity may be associated with postoperative axial pain in degenerative cervical myelopathy patients. This finding may inspire new therapeutic ideas for patients with preoperative axial pain.
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