ArticleScientific reports2023
Heart failure decouples the precuneus in interaction with social cognition and executive functions.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Neurological impairments in Duchenne muscular dystrophy: A comprehensive review.Acta neurologica Belgica · 2026Review
- Neural Patterns of Social Pain in the Brain-Wide Representations Across Social Contexts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain topology and cognitive outcomes after cardiac arrest: A graph theoretical analysis of fMRI data.Neuroimage. Reports · 2025Article
- Frailty and Heart Failure: Clinical Insights, Patient Outcomes and Future Directions.Cardiac failure review · 2025Review
- Factors Influencing the Development and Severity of Cognitive Decline in Patients with Chronic Heart Failure.Medicina (Kaunas, Lithuania) · 2024Article
- Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia.Alzheimer's research & therapy · 2024Article
- Functional connectivity in resting-state networks relates to short-term global cognitive functioning in cardiac arrest survivors.Human brain mapping · 2024Article
- Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.Aging medicine (Milton (N.S.W)) · 2024Review
- Cortical alterations associated with executive function deficits in youth with a congenital heart defect.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging increases the risk to develop Alzheimer's disease. Cardiovascular diseases might accelerate this process. Our study aimed at investigating the impact of heart failure on brain connectivity using functional magnetic resonance imaging at resting state. Here we show brain connectivity alterations related to heart failure and cognitive performance. Heart failure decreases brain connectivity in the precuneus. Precuneus dysconnectivity was associated with biomarkers of heart failure-left ventricular ejection fraction and N-terminal prohormone of brain natriuretic peptide-and cognitive performance, predominantly executive function. Meta-analytical data-mining approaches-conducted in the BrainMap and Neurosynth databases-revealed that social and executive cognitive functions are mainly associated with those neural networks. Remarkably, the precuneus, as identified in our study in a mid-life cohort, represents one central functional hub affected by Alzheimer's disease. A long-term follow-up investigation in our cohort after approximately nine years revealed more severe cognitive impairment in the group with heart failure than controls, where social cognition was the cognitive domain mainly affected, and not memory such as in Alzheimer's disease. In sum, our results indicate consistently an association between heart failure and decoupling of the precuneus from other brain regions being associated with social and executive functions. Further longitudinal studies are warranted elucidating etiopathological mechanisms.
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