ArticleCommunications biology2023
The metazoan landscape of mitochondrial DNA gene order and content is shaped by selection and affects mitochondrial transcription.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
- De Novo Assembly and Comparative Analysis of the Complete Mitochondrial Genome ofEcology and evolution · 2026Article
- Morphological Characterization and Complete Mitochondrial Genome of a New Epizoic Hexamerous Brittle StarEcology and evolution · 2026Article
- Complete Mitochondrial Genome Analysis of Atypopenaeus stenodactylus and Its Phylogenetic Significance Within Penaeidae.Biochemical genetics · 2026Article
- Towards a mitogenomic phylogeny of mud dragons (Kinorhyncha): two new mitogenomes from the Pycnophyidae family.Scientific reports · 2026Article
- Patterns and determinants of mitogenomic evolution in Bilateria.Nature communications · 2026Article
- Evidence of Relaxed Selection in the Mitochondrial Genomes of Phototrophic Paulinella Lineages.Genome biology and evolution · 2026Article
- From Rigid Order to Radical Variation: Mitogenome Evolution in the Main Lineages of a Lesser-Known Animal Phylum (Gastrotricha).Genome biology and evolution · 2026Article
- Hypoxia leads to reduced mito-nuclear gene expression and increased mtDNA transcriptional pausing in human cells.Communications biology · 2026Article
- Single-cell and pseudobulk analyses reveal hidden mitochondrial expression imbalance in gastric cancer.Frontiers in genetics · 2026Article
- The Copepoda mitogenome as a dynamic evolutionary landscape.PloS one · 2026Article
- Mitogenomic Characterization, Genetic Diversity, and Matrilineal Phylogenetic Insights of the Marbled Goby (International journal of molecular sciences · 2025Article
- Article
- The Complete Mitochondrial Genome ofGenes · 2025Article
- A phased chromosome-level genome of the annelid tubeworm Galeolaria caespitosa.The Journal of heredity · 2025Article
- Continuous infiltration and evolutionary trajectory of nuclear organelle DNA inGenome research · 2025Article
- Enhanced dynamicity: evolutionary insights into amphibian mitogenomes architecture.BMC genomics · 2025Article
- Pervasive Mitochondrial tRNA Gene Loss in Clade B of Haplosclerid Sponges (Porifera, Demospongiae).Genome biology and evolution · 2025Article
- Comprehensive analysis of 111 Pleuronectiformes mitochondrial genomes: insights into structure, conservation, variation and evolution.BMC genomics · 2025Article
- Comparative analysis of mitogenomes in sixZooKeys · 2025Article
- qGO: a novel method for quantifying the diversity of mitochondrial genome organization.BMC genomics · 2024Article
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2 authors.
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Abstract
Mitochondrial DNA (mtDNA) harbors essential genes in most metazoans, yet the regulatory impact of the multiple evolutionary mtDNA rearrangements has been overlooked. Here, by analyzing mtDNAs from ~8000 metazoans we found high gene content conservation (especially of protein and rRNA genes), and codon preferences for mtDNA-encoded tRNAs across most metazoans. In contrast, mtDNA gene order (MGO) was selectively constrained within but not between phyla, yet certain gene stretches (ATP8-ATP6, ND4-ND4L) were highly conserved across metazoans. Since certain metazoans with different MGOs diverge in mtDNA transcription, we hypothesized that evolutionary mtDNA rearrangements affected mtDNA transcriptional patterns. As a first step to test this hypothesis, we analyzed available RNA-seq data from 53 metazoans. Since polycistron mtDNA transcripts constitute a small fraction of the steady-state RNA, we enriched for polycistronic boundaries by calculating RNA-seq read densities across junctions between gene couples encoded either by the same strand (SSJ) or by different strands (DSJ). We found that organisms whose mtDNA is organized in alternating reverse-strand/forward-strand gene blocks (mostly arthropods), displayed significantly reduced DSJ read counts, in contrast to organisms whose mtDNA genes are preferentially encoded by one strand (all chordates). Our findings suggest that mtDNA rearrangements are selectively constrained and likely impact mtDNA regulation.
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