Evidence map›Paper›PMID 36690410›Full record

ArticleAnnals of the rheumatic diseases2023

3D genome alterations in T cells associated with disease activity of systemic lupus erythematosus.

Ming Zhao, Delong Feng, Longyuan Hu, Lin Liu, Jiali Wu, Zhi Hu, Haojun Long, Qiqi Kuang, Lianlian Ouyang, Qianjin Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Aberrant Enhancer Regulation, Phase Separation, and Autoimmune Diseases.Clinical reviews in allergy & immunology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ming Zhao *Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China zhaoming307@csu.edu.cn qianlu5860@pumcderm.cams.cn.ORCID 0000-0002-1320-1093
Delong Feng *Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Longyuan HuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Lin LiuEpigenetic Group, Frasergen Bioinformatics Co, Ltd, Wuhan, China.
Jiali WuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Zhi HuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Haojun LongDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Qiqi KuangDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Lianlian OuyangDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Qianjin LuDepartment of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China zhaoming307@csu.edu.cn qianlu5860@pumcderm.cams.cn.ORCID 0000-0002-4192-4897
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThree-dimensional (3D) genome alterations can dysregulate gene expression by rewiring physical interactions within chromosomes in a tissue-specific or cell-specific manner and lead to diseases. We aimed to elucidate the 3D genome structure and its role in gene expression networks dysregulated in systemic lupus erythematosus (SLE).

methodsWe performed Hi-C experiments using CD4

resultsWe deciphered the 3D chromosome organisation in T cells of patients with SLE and found it was clearly distinct from that of HCs and closely associated with the disease activity of SLE. Importantly, we identified loops within chromosomes associated with the disease activity of SLE and differentially expressed genes and found some key histone modifications close to these loops. Moreover, we demonstrated the contribution of the transcription factor SPI1, whose motif is located in the altered loop in SLE, to the overexpression of interferon pathway gene. In addition, we identified the potential influences of genetic variations in 3D genome alterations in SLE.

conclusionsOur results highlight the 3D genome structure alterations associated with SLE development and provide a foundation for future interrogation of the relationships between chromosome structure and gene expression control in SLE.

Indexed as

Lupus Erythematosus, SystemicCD4-Positive T-LymphocytesGene Expression RegulationHumansTranscription FactorsTranscription Factorsautoimmune diseaseslupus erythematosus, systemicT-lymphocyte subsets

Identifiers

PMID36690410
PMCPMC9887402
OpenAlexW4294043869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.