Evidence map›Paper›PMID 36690405›Full record

ArticleBMJ open2023

Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study.

Viviana Fajardo Martinez, Dajie Zhang, Sophia Paiola, Thalia Mok, Mary C Cambou, Tara Kerin, Rashmi Rao, Patricia Brasil, Fatima Ferreira, Trevon Fuller and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 5 countries.

Viviana Fajardo Martinez *Pediatrics, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID 0000-0002-9000-7032
Dajie Zhang *Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen and Leibniz-ScienceCampus Primate Cognition, Göttingen, Germany.ORCID 0000-0001-6050-7426
Sophia PaiolaPediatrics, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Thalia MokObstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Mary C CambouInternal Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID 0000-0003-2527-2574
Tara KerinPediatrics, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID 0000-0003-2655-5605
Rashmi RaoObstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Patricia BrasilAcute Febrile Illnesses, FIOCRUZ, Rio de Janeiro, Brazil.
Fatima FerreiraPediatrics, Escola de Medicina, Universidade do Rio de Janeiro, Rio de Janeiro, Brazil.
Trevon FullerFIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0001-9954-4267
Debika BhattacharyaInternal Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Suan-Sin FooCancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Weiqiang ChenCancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jae JungCancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Christa EinspieleriDN - interdisciplinary Developmental Neuroscience, Division of Phoniatrics, Medical University of Graz, Graz, Austria.ORCID 0000-0002-7875-0632
Peter B MarschikChild and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen and Leibniz-ScienceCampus Primate Cognition, Göttingen, Germany.ORCID 0000-0001-8932-0980
Karin Nielsen-SainesPediatrics, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA knielsen@mednet.ucla.edu.ORCID 0000-0002-1742-5211
University of California, Los Angeles · USCleveland Clinic Lerner College of Medicine · USMedical University of Graz · ATFundação Oswaldo Cruz · BR

Funding

Postdoctoral Training in Global AIDS Prevention ResearchT32MH080634 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Pamina Mae Gorbach · 2007 to 2026
$6.4M
Genetic evolution, pathogenesis and immune responses in mother to child transmission of ZIKVR01AI140718 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG, JUNG, JAE U · 2018 to 2022
$3.8M
Molecular regulatory mechanism of Zika virus-induced intracranial calcificationsR00DE028573 · NIDCR · CLEVELAND CLINIC LERNER COM-CWRU · PI CHEN, WEIQIANG · 2022 to 2024
$747k
Molecular regulatory mechanism of Zika virus-induced intracranial calcificationsK99DE028573 · NIDCR · CLEVELAND CLINIC LERNER COM-CWRU · PI CHEN, WEIQIANG · 2020 to 2021
$188k
NIAID NIH HHS R01 AI140718NIDCR NIH HHS K99 DE028573NIDCR NIH HHS R00 DE028573NIMH NIH HHS T32 MH080634
6 · The paper itself

Abstract

objectiveTo evaluate neuromotor repertoires and developmental milestones in infants exposed to antenatal COVID-19.

designLongitudinal cohort study.

settingHospital-based study in Los Angeles, USA and Rio de Janeiro, Brazil between March 2020 and December 2021.

participantsInfants born to mothers with COVID-19 during pregnancy and prepandemic control infants from the Graz University Database.

interventionsGeneral movement assessment (GMA) videos between 3 and 5 months post-term age were collected and clinical assessments/developmental milestones evaluated at 6-8 months of age. Cases were matched by gestational age, gender and post-term age to prepandemic neurotypical unexposed controls from the database.

main outcome measuresMotor Optimality Scores Revised (MOS-R) at 3-5 months. Presence of developmental delay (DD) at 6-8 months.

results239 infants were enrolled; 124 cases (83 in the USA/41 in Brazil) and 115 controls. GMA was assessed in 115 cases and 115 controls; 25% were preterm. Median MOS-R in cases was 23 (IQR 21-24, range 9-28) vs 25 (IQR 24-26, range 20-28) in controls, p<0.001. Sixteen infants (14%) had MOS-R scores <20 vs zero controls, p<0.001. At 6-8 months, 13 of 109 case infants (12%) failed to attain developmental milestones; all 115 control infants had normal development. The timing of maternal infection in pregnancy (first, second or third trimester) or COVID-19 disease severity (NIH categories asymptomatic, mild/moderate or severe/critical) was not associated with suboptimal MOS-R or DD. Maternal fever in pregnancy was associated with DD (OR 3.7; 95% CI 1.12 to 12.60) but not suboptimal MOS-R (OR 0.25; 95% CI 0.04 to 0.96).

conclusionsCompared with prepandemic controls, infants exposed to antenatal COVID-19 more frequently had suboptimal neuromotor development.

Indexed as

COVID-19Pregnancy Complications, InfectiousBrazilCohort StudiesFemaleHumansInfantInfant, NewbornLongitudinal StudiesPregnancyCOVID-19Maternal medicinePaediatric infectious disease & immunisationPaediatric neurology

Identifiers

PMID36690405
PMCPMC9871864
OpenAlexW4317802898

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.