ArticleJournal of molecular biology2023
Phase Separation in Biology and Disease; Current Perspectives and Open Questions.
Open access · hybridAbstract readConference Proceedings
In one paragraph
Article in Journal of molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
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Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
- Fusion protein condensate formation via coiled-coil domains.Protein science : a publication of the Protein Society · 2026Article
- The Polymers of Life: Exploring Cellular Function Through Polymer Concepts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions.Nature cell biology · 2026Article
- Dynamic yet well-defined organization of the FUS RGG3 dense phase.Communications chemistry · 2026Article
- The filamentous ultrastructure of the PopZ condensate is required for its cellular function.Nature structural & molecular biology · 2026Article
- Allostery in Biomolecular Condensates.Journal of molecular biology · 2026Review
- The Axon as a Self-Modifying Computational System: Autonomous Inference, Adaptive Propagation, and AI-Enabled Mechanistic Insight.International journal of molecular sciences · 2026Review
- Sequence-dependent co-condensation of Lsr2 with DNA elucidates the mechanism of genome compaction in Mycobacterium tuberculosis.Nucleic acids research · 2026Article
- Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.bioRxiv : the preprint server for biology · 2025Article
- Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions.bioRxiv : the preprint server for biology · 2025Article
- Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior.JACS Au · 2025Article
- Beyond Electrostatic Interactions: H-Bond Dynamics in Arginine- versus Lysine-Rich Biocondensates.The journal of physical chemistry letters · 2025Article
- Physics of Protein Aggregation in Normal and Accelerated Brain Aging.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation.JACS Au · 2025Article
- Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions of tau into amyloid fibrils.Science advances · 2025Article
- A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization.Molecular cell · 2025Article
- Unveiling the dynamic drivers: phase separation's pivotal role in stem cell biology and therapeutic potential.Stem cell research & therapy · 2025Review
- Coacervates Composed of Low-Molecular-Weight Compounds- Molecular Design, Stimuli Responsiveness, Confined Reaction.Advanced biology · 2025Review
- Functional specificity in biomolecular condensates revealed by genetic complementation.Nature reviews. Genetics · 2025Review
- Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen.Communications biology · 2025Article
Corrections and comments
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Authors and funding
22 authors at 17 institutions in 5 countries.
Steven BoeynaemsDepartment of Molecular and Human Genetics, Therapeutic Innovation Center (THINC), Center for Alzheimer's and Neurodegenerative Diseases (CAND), Dan L Duncan Comprehensive Cancer Center (DLDCCC), Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address: https://twitter.com/BoeynaemsSteven.
Shasha ChongDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: https://twitter.com/schong_ustc.
Jörg GsponerMichael Smith Laboratories, Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada. Electronic address: https://twitter.com/ubcmsl.
Liam HoltNew York University School of Medicine, Institute for Systems Genetics, New York, NY 10016, USA. Electronic address: https://twitter.com/liamholtlab.
Dragomir MilovanovicLaboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany. Electronic address: https://twitter.com/DZNE_de.
Diana M MitreaDewpoint Therapeutics, Boston, MA, USA. Electronic address: https://twitter.com/DiaMitrea.
Oliver Mueller-CajarSchool of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore. Electronic address: https://twitter.com/omc111.
Bede PortzDewpoint Therapeutics, Boston, MA, USA. Electronic address: https://twitter.com/ysptsps.
John F ReillyNereid Therapeutics, Boston, MA, USA. Electronic address: https://twitter.com/NereidTx.
Christopher D ReinkemeierDepartment of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland. Electronic address: https://twitter.com/ReinkemeierCD.
Benjamin R SabariLaboratory of Nuclear Organization, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: https://twitter.com/bsabari.
Serena SanulliDepartment of Genetics, Stanford University, Palo Alto, CA 94304, USA. Electronic address: https://twitter.com/seresanu.
James ShorterDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: https://twitter.com/shorterlab.
Emily SontagDepartment of Biological Sciences, Marquette University, Milwaukee, WI, USA. Electronic address: https://twitter.com/EmSontagMU.
Lucia StraderDepartment of Biology, Duke University, Durham, NC 27708, USA. Electronic address: https://twitter.com/LabStrader.
Jeanne StachowiakUniversity of Texas at Austin, Department of Biomedical Engineering, Austin, TX, USA. Electronic address: https://twitter.com/StachowiakLab.
Stephanie C WeberDepartment of Biology, McGill University, Montreal, QC H3A 1B1, Canada. Electronic address: https://twitter.com/weber_lab.
Michael WhiteFaze Medicines, Cambridge, MA, USA.
Huaiying ZhangDepartment of Biological Sciences, Mellon College of Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: https://twitter.com/lab_zhang.
Markus ZweckstetterGerman Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Str. 3a, 37075 Göttingen, Germany; Max Planck Institute for Multidisciplinary Sciences, Department of NMR-based Structural Biology, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address: https://twitter.com/mz_science.
Shana Elbaum-GarfinkleDepartment of Biochemistry, The Graduate Center of the City University of New York, New York, NY, USA; Structural Biology Initiative, Advanced Science Research Center, City University of New York, New York, NY, USA. Electronic address: https://twitter.com/SElbaumG.
Richard KriwackiDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN, USA. Electronic address: https://twitter.com/kriwacki.
German Center for Neurodegenerative Diseases · DEBaylor College of Medicine · USCalifornia Institute of Technology · USCarnegie Mellon University · USDuke University · USETH Zurich · CHMarquette University · USMcGill University · CANanyang Technological University · SGNew York University · USPalo Alto University · USSt. Jude Children's Research Hospital · USThe Graduate Center, CUNY · USThe University of Texas at Austin · USThe University of Texas Southwestern Medical Center · USUniversity of British Columbia · CAUniversity of Pennsylvania · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE J. BAKER · 1985 to 2026
$166.9MProject 4U54CA243124 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MULLIGHAN, CHARLES G. · 2019 to 2023
$10.5MEnvironmental Biosensors in the Oligodendrocyte LineageR35NS111604 · NINDS · ADVANCED SCIENCE RESEARCH CENTER · PI Patrizia Casaccia · 2019 to 2026
$9.1MThe Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal DementiaR01NS127186 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOLT, LIAM J, PHATNANI, HEMALI · 2021 to 2025
$8.2MProtein Networks as Synergistic Drivers of Membrane RemodelingR35GM139531 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Jeanne Casstevens Stachowiak · 2021 to 2026
$4.0MDefining the mechanistic basis of a prion disaggregaseR01GM099836 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SHORTER, JAMES · 2013 to 2024
$3.9MUnderstanding Phase Separation in Biology and DiseaseR35GM131891 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RICHARD W KRIWACKI · 2019 to 2026
$3.3MNIGMS administrative equipment supplement for R35 GM136338-02R35GM136338 · NIGMS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Lucia Strader · 2020 to 2026
$3.2MCancer under pressure: Mechanisms of adaptation to compressive stressR37CA240765 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOLT, LIAM J · 2019 to 2025
$3.2MRole of Phase separation by fusion oncoproteins in oncogenesisR01CA246125 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DENIZ, ASHOK A, KRIWACKI, RICHARD W · 2020 to 2024
$3.2MPhase separation-induced nuclear organization in ALT CancerU01CA260851 · NCI · CARNEGIE-MELLON UNIVERSITY · PI ZHANG, HUAIYING · 2020 to 2024
$2.6MHarnessing the chromatin conformational code for epigenetic regulationDP2GM149752 · NIGMS · STANFORD UNIVERSITY · PI SANULLI, SERENA · 2022 to 2025
$2.3MNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA246125NCI NIH HHS R37 CA240765NCI NIH HHS U01 CA260851NCI NIH HHS U54 CA243124NIA NIH HHS R21 AG065854NIA NIH HHS R21 AG079609NIGMS NIH HHS DP2 GM149752NIGMS NIH HHS R01 GM099836NIGMS NIH HHS R01 GM132447NIGMS NIH HHS R01 GM138690NIGMS NIH HHS R01 GM147583NIGMS NIH HHS R35 GM131891NIGMS NIH HHS R35 GM136338NIGMS NIH HHS R35 GM139531NINDS NIH HHS R01 NS127186NINDS NIH HHS R35 NS111604
Abstract
In the past almost 15 years, we witnessed the birth of a new scientific field focused on the existence, formation, biological functions, and disease associations of membraneless bodies in cells, now referred to as biomolecular condensates. Pioneering studies from several laboratories [reviewed in
Indexed as
Biomolecular CondensatesDiseasePhase TransitionHumansbiomolecular condensatesmembraneless organellesphase separation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.