Evidence map›Paper›PMID 36689804›Full record

ArticleThrombosis research2023

Left ventricular systolic dysfunction during acute pulmonary embolism.

Rafael Cires-Drouet, Allison LaRocco, Danielle Soldin, Thomas John, Shahab Toursavadkohi, Khanjan Nagarsheth, Siamak Dahi, Justin Marsella, Minerva Mayorga-Carlin, John D Sorkin and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
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Article in Thrombosis research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Rafael Cires-DrouetDepartment of Surgery, University of Maryland, Baltimore, MD, USA. Electronic address: rcires@som.umaryland.edu.
Allison LaRoccoDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Danielle SoldinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Thomas JohnDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Shahab ToursavadkohiDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
Khanjan NagarshethDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
Siamak DahiDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
Justin MarsellaDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
Minerva Mayorga-CarlinDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
John D SorkinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Baltimore VA Geriatrics Research, Education, and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Kevin JonesDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; The R. Adams Cowley Shock Trauma Center, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA.
Daniel HaaseDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; The R. Adams Cowley Shock Trauma Center, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA.
Susie N HongDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Brajesh K LalDepartment of Surgery, University of Maryland, Baltimore, MD, USA; Vascular Service, Veterans Affairs Medical Center, Baltimore, MD, USA.
Bartley GriffithDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
Gautam RamaniDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Bradley TaylorDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
University of Maryland, Baltimore · USBaltimore VA Medical Center · USVeterans Health Administration · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
NIA NIH HHS P30 AG028747
6 · The paper itself

Abstract

backgroundHeart failure increases the risk of death in acute pulmonary embolism (PE). The role of the left ventricle (LV) in acute PE is not well defined.

objectiveTo identify the prevalence of LV systolic dysfunction, morphology, and prognosis of the LV during an acute PE.

methodsRetrospective study (26-months) of patients diagnosed with an acute PE presenting with LV systolic dysfunction at the University of Maryland.

resultsAmong 769 acute PE patients, 78 (10.5 %) had LV systolic dysfunction and 42 (53.8 %) had history of cardiac disease. Patients without history of cardiac disease were younger (mean age [SD] 54.9 [16.8] vs. 62.6 [16.6]; p = 0.04), had a higher BMI (31.2 [12.2] vs. 29.2 [7.7]; p = 0.005), and less hypertension (20 [34.5 %] vs. 38 [65.5 %]; p = 0.0005). A massive PE was most common in patients without history of cardiac disease (8[22.2 %] vs. 2[4.7 %], p = 0.02). There was no difference in clot burden, but right ventricular strain was more frequently seen in patients without history cardiac disease in the initial CT (p = 0.001). The median troponin and lactate were similar in both groups. In 41 patients with follow-up echocardiograms, improvement in LVEF% was observed in patients without cardiac history (median Δ LVEF% [IQR]; 20 [6.2-25.0]). While patients with cardiac disease did not demonstrate similar changes (median Δ LVEF% [IQR]; 0 [-5-17.5]; p = 0.01). In hospital mortality was 12.8 % with no difference between both groups (p = 0.17).

conclusionPulmonary embolism can be associated with LV systolic dysfunction, even in patients without history of cardiac disease.

Indexed as

Pulmonary EmbolismVentricular Dysfunction, LeftVentricular Dysfunction, RightAcute DiseaseEchocardiographyHumansRetrospective StudiesLeft ventricle dysfunctionLow EFPulmonary embolism

Identifiers

PMID36689804
PMCPMC10989403
OpenAlexW4317627109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.