ArticleProblemy endokrinologii2023
[The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].
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222 authors at 20 institutions in 12 countries.
A G ArutyunovAssociation «Eurasian Association of Therapists»; National Institute of Health named after S. Avdalbekyan.
E I TarlovskayaAssociation «Eurasian Association of Therapists»; Privolzhsky Research Medical University.
G R GalstyanScientific Medical Research Center of Endocrinology of the Ministry of Health of Russia.
T I BatlukAssociation «Eurasian Association of Therapists»; Pirogov Russian National Research Medical University.
R A BashkinovAssociation «Eurasian Association of Therapists»; North-Western State Medical University named after I.I. Mechnikov.
G G ArutyunovAssociation «Eurasian Association of Therapists»; Pirogov Russian National Research Medical University.
Yu N BelenkovSechenov University.
A O KonradiAlmazov National Medical Research Centre" of the Ministry of Health of the Russian Federation.
Yu M LopatinVolgograd State Medical University.
A P RebrovSaratov State Medical University named after V.I. Razumovsky.
S N TereshchenkoNational medical research center of cardiology.
A I ChesnikovaRostov State Medical University.
H G HayrapetyanErebouni Cardiology Center.
A P BabinNicolae Testemitanu State University of Medicine and Pharmacy.
I G BakulinNorth-Western State Medical University named after I.I. Mechnikov.
N V BakulinaNorth-Western State Medical University named after I.I. Mechnikov.
L A BalykovaOgarev Mordovia State University.
A S BlagonravovaPrivolzhsky Research Medical University.
M V BoldinaPrivolzhsky Research Medical University.
M I ButomoPavlov First State Medical University of St. Petersburg.
A R VaisbergPrivolzhsky Research Medical University.
A S GalyavichThe Republican Center for Cardiovascular Diseases of State Autonomous Institution of Health «Interregional Clinical Diagnostic Center»; Kazan State Medical University.
V V GomonovaNorth-Western State Medical University named after I.I. Mechnikov.
N Yu GrigoryevaNational Research Lobachevsky State University of Nizhni Novgorod.
I V GubarevaSamara State Medical University, Internal Diseases Department.
I V DemkoKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky; Regional state budgetary healthcare institution «Regional Clinical Hospital».
A V EvzerikhinaKrasnogorsk city hospital №1.
A V ZharkovKirovsk Interdistrict Hospital.
A A ZateishchikovaCity Hospital №51.
U K KamilovaThe Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation.
Z F KimMedical Center «GAUZ GKB №7».
T Yu KuznetsovaPetrozavodsk State University.
A N KulikovPavlov First State Medical University of St. Petersburg.
N A V LarevaChita State Medical Academy.
E V MakarovaPrivolzhsky Research Medical University.
S V MalchikovaKirov State Medical University.
S V NedogodaVolgograd State Medical University.
M M PetrovaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky.
I G PochinkaPrivolzhsky Research Medical University; Privolzhsky Research Medical University, City Clinical Hospital №13 of Nizhniy Novgorod.
K V ProtasovIrkutsk State Medical Academy of Postgraduate Education.
D N ProtsenkoPirogov Russian National Research Medical University; Moscow City Clinical Hospital №40.
D Yu RuzanovEducational Institution «Gomel State Medical University».
S A SaiganovNorth-Western State Medical University named after I.I. Mechnikov.
A Sh SarybaevNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
N M SeleznevaOgarev Mordovia State University.
A B SugralievAsfendiyarov Kazakh National Medical University.
I V FominPrivolzhsky Research Medical University.
O V KhlynovaPerm State Medical University named after E.A. Vagner.
O Yu ChizhovaNorth-Western State Medical University named after I.I. Mechnikov.
I I ShaposhnikSouth-Ural State Medical University.
D A SchukarevKirovsk Interdistrict Hospital.
A K AbdrakhmanovaKazakh University of Continuing Education; Clinical Infectious Diseases Hospital named after I. Zhekenovа.
S A AvetisyanYerevan State Medical University.
H G AvoyanErebouni Cardiology Center.
K K AzaryanErebouni Cardiology Center.
G T AimakhanovaAsfendiyarov Kazakh National Medical University.
D A AyypovaNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
A Ch AkunovNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
M K AlievaNorth-Western State Medical University named after I.I. Mechnikov.
A R AlmukhambedovaCentral Clinical Hospital of the Office of the President of RF.
A V AparkinaSaratov State Medical University named after V.I. Razumovsky.
O R AruslanovaPerm Regional Clinical Cardiological Dispensary.
E Yu AshinaPrivolzhsky Research Medical University.
O Na Yu BadinaThe Volga District Medical Centre, Federal Medical and Biological Agency of Russia.
O Yu BaryshevaPetrozavodsk State University.
A S BatchaevaPirogov Russian National Research Medical University.
A M BitievaNorth-Western State Medical University named after I.I. Mechnikov.
I U BikhteevNorth-Western State Medical University named after I.I. Mechnikov.
N A BorodulinaPerm Regional Clinical Cardiological Dispensary.
M V BraginNorth-Western State Medical University named after I.I. Mechnikov.
V A BrazhnikCity Hospital №51.
A M BuduClinical City Hospital №1.
G A BykovaPerm State Medical University named after E.A. Vagner.
K R VagapovaFSBI "Polyclinic №1 of the Administrative Directorate of the President of the Russian Federation.
D D VarlamovaPetrozavodsk State University.
N N VezikovaPetrozavodsk State University.
E A VerbitskayaRegional state budgetary healthcare institution «Regional Clinical Hospital».
O E VilkovaNational Research Lobachevsky State University of Nizhni Novgorod.
E A VinnikovaNorth-Western State Medical University named after I.I. Mechnikov.
V V VustinaPerm Regional Clinical Hospital.
E A GalovaPrivolzhsky Research Medical University.
V V GenkelSouth-Ural State Medical University.
D B GillerSechenov University.
E I GorsheninaOgarev Mordovia State University.
E V GrigoryevaSaratov State Medical University named after V.I. Razumovsky.
E Yu GubarevaSamara State Medical University, Internal Diseases Department.
G M DabylovaAsfendiyarov Kazakh National Medical University.
A I DemchenkoSamara State Medical University, Internal Diseases Department.
O Yu DolgikhState Budgetary Institution of Healthcare of the Samara Region «Chapaevskaya Central City Hospital», Chapaevsk.
M Y DuishobaevNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
D S EvdokimovNorth-Western State Medical University named after I.I. Mechnikov.
K E EgorovaRepublic hospital n.a. V.A. Baranov.
A N ErmilovaAssociation «Eurasian Association of Therapists»; «Empathy» (mental health centre).
A E ZheldybaevaAsfendiyarov Kazakh National Medical University.
N V ZarechnovaThe Volga District Medical Centre, Federal Medical and Biological Agency of Russia.
Yu D ZiminaCity Clinical Hospital №25.
S Yu IvanovaState Budgetary Medical Institution Republic of Karelia Hospital for Veterans.
E Yu IvanchenkoPrivolzhsky Research Medical University.
M V IlinaKirovsk Interdistrict Hospital.
M V KazakovtsevaKirov State Medical University.
E V KazymovaPrivate Healthcare Institution «Clinical Hospital RZHD Meditsyna at Samara railway station».
Yu S KalininaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky.
N A KamardinaThe Volga District Medical Centre, Federal Medical and Biological Agency of Russia.
A M KarachenovaChita State Medical Academy.
I A KaretnikovIrkutsk regional clinical hospital of Conferred Order of Merit.
N A KaroliSaratov State Medical University named after V.I. Razumovsky.
M Kh KarsievNorth-Western State Medical University named after I.I. Mechnikov.
D S KaskaevaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky.
K F KasymovaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky.
Zh B KerimbekovaNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
E S KimMedical Center «GAUZ GKB №7».
N V KiselevaNizhniy Novgorod City Hospital №40.
D A KlimenkoSamara State Medical University, Internal Diseases Department.
A V KlimovaPirogov Russian National Research Medical University; Moscow City State Outpatient Hospital №13440.
O V KovalishenaPrivolzhsky Research Medical University.
S V KozlovCity Hospital №51.
E V KolmakovaNorth-Western State Medical University named after I.I. Mechnikov.
T P KolchinskayaMunicipal Autonomous Healthcare Institution of the Order of the Red Banner of Labour «City Clinical Hospital №1».
M I KolyadichSouth-Ural State Medical University; Municipal Autonomous Healthcare Institution of the Order of the Red Banner of Labour «City Clinical Hospital №1».
O V KondryakovaSamara State Medical University, Internal Diseases Department.
M P KonovalNorth-Western State Medical University named after I.I. Mechnikov.
D Yu KonstantinovSamara State Medical University, Internal Diseases Department.
E A KonstantinovaSamara State Medical University, Internal Diseases Department.
V A KordyukovaPrivolzhsky Research Medical University.
E V KorolevaNational Research Lobachevsky State University of Nizhni Novgorod; City clinical hospital №5 of Nizhniy Novgorod, National Research Lobachevsky State University of Nizhni Novgorod.
A Yu KraposhinaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky; Regional state budgetary healthcare institution «Regional Clinical Hospital».
T V KryukovaAssociation «Eurasian Association of Therapists».
A S KuznetsovaSouth-Ural State Medical University.
T Yu KuzminaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky.
K V KuzmichevPrivolzhsky Research Medical University, City Clinical Hospital №13 of Nizhniy Novgorod.
Ch K KulchoroevaNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
T V KuprinaPetrozavodsk State University.
I A M KuranovaGorodetskaya Central City Hospital of Nizhniy Novgorod Region.
L Va V KurenkovaRepublic hospital n.a. S.V. Katkov.
N Yu KurchuginaSamara State Medical University, Internal Diseases Department.
N A KushubakovaNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
V I LevankovaPetrozavodsk City polyclinic №1.
A A LedyaevaVolgograd State Medical University.
T V LisunMoscow City Clinical Hospital №40.
V E LisyanskayaPavlov First State Medical University of St. Petersburg.
N A LyubavinaPrivolzhsky Research Medical University.
N A MagdeevaSaratov State Medical University named after V.I. Razumovsky.
K V MazalovThe Volga District Medical Centre, Federal Medical and Biological Agency of Russia.
V I MayseenkoEducational Institution «Gomel State Medical University».
A S MakarovaIrkutsk State Medical Academy of Postgraduate Education.
A M MaripovNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
N V MarkovPavlov First State Medical University of St. Petersburg.
A A MarusinaKirovsk Interdistrict Hospital.
E S MelnikovAssociation «Eurasian Association of Therapists»; North-Western State Medical University named after I.I. Mechnikov.
A I MetlinskayaPavlov First State Medical University of St. Petersburg.
N B MoiseenkoNational Research Lobachevsky State University of Nizhni Novgorod.
F N MuradovaPrivolzhsky Research Medical University.
R G MuradyanGlobal Medical System clinics and hospitals.
Sh N MusaelyanYerevan State Medical University.
E S NekaevaPrivolzhsky Research Medical University.
N M NikitinaSaratov State Medical University named after V.I. Razumovsky.
S E NifontovPavlov First State Medical University of St. Petersburg.
E Yu ObolentsevaPavlov First State Medical University of St. Petersburg.
A A ObukhovaPavlov First State Medical University of St. Petersburg.
B B OgurlievaPirogov Russian National Research Medical University; Moscow City Clinical Hospital №4.
A A OdegovaKirov State Medical University.
Yu V OmarovaPrivolzhsky Research Medical University.
N A OmurzakovaNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
Sh O OspanovaAsfendiyarov Kazakh National Medical University.
V A PavlovaPavlov First State Medical University of St. Petersburg.
E V Pakhomova PakhomovaGBUZ RK «Republican tuberculosis dispensary».
L D PetrovHealth Center of Briceni.
S S PlastininaPrivolzhsky Research Medical University.
D A PlatonovCity Hospital №51.
V Aya A PogrebetskayaSBHI of Nizhniy Novgorod Region «City Clinical Hospital №38».
D V PolyakovPirogov Russian National Research Medical University.
D S PolyakovPrivolzhsky Research Medical University.
E Enko V PonomarenkoMedical center «Zimamed».
L L PopovaSamara State Medical University, Internal Diseases Department.
A A PotaninPavlov First State Medical University of St. Petersburg.
N A ProkofievaNorth-Western State Medical University named after I.I. Mechnikov.
Yu D RabikPavlov First State Medical University of St. Petersburg.
N A RakovPrivolzhsky Research Medical University.
A N RakhimovThe Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation.
N A RozanovaKrasnogorsk city hospital №1.
I V SamusKemerovo regional clinical psychiatric hospital.
S SerikbolkyzyAsfendiyarov Kazakh National Medical University.
Ya A SidorkinaCity Hospital №51.
A A SimonovNorth-Western State Medical University named after I.I. Mechnikov.
V V SkachkovaPerm Regional Clinical Hospital.
R D SkvortsovaPavlov First State Medical University of St. Petersburg.
D S SkuridinPavlov First State Medical University of St. Petersburg.
D V SolovievaNational Research Lobachevsky State University of Nizhni Novgorod.
I A SolovievaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky; Regional state budgetary healthcare institution «Regional Clinical Hospital».
I M SukhomlinovaSaint-Petersburg hospital for veterans.
A G SushilovaNorth-Western State Medical University named after I.I. Mechnikov.
D R TagaevaThe Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation.
Yu V TitoykinaOgarev Mordovia State University.
E P TikhonovaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky.
D S TokminLabs of the Future.
A A TolmachevaNovosibirsk State Medical University; SBHCI of Novosibirsk region «Clinical Polyclinic №3».
M S TorgunakovaKrasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky.
K V TrenoginaPerm Regional Clinical Hospital.
N Aya A TrostyanetskayaNorth-Western State Medical University named after I.I. Mechnikov.
D A TrofimovKazan State Medical University; Medical Center «GAUZ GKB №7».
M A TrubnikovaAssociation «Eurasian Association of Therapists»; LLC "Fresenius Medical Care Kuban".
A A TulichevPrivolzhsky Research Medical University; SBHI of Nizhniy Novgorod region City Clinical Hospital №3.
A T TursunovaAsfendiyarov Kazakh National Medical University.
N D UlanovaPrivolzhsky Research Medical University, City Clinical Hospital №13 of Nizhniy Novgorod.
O V FatenkovSamara State Medical University, Internal Diseases Department.
O V FedorishinaIrkutsk State Medical Academy of Postgraduate Education.
T S FilNorth-Western State Medical University named after I.I. Mechnikov.
I Yu FominaPrivolzhsky Research Medical University; SBHI of Nizhniy Novgorod region City Outpatient Hospital №1.
I S FominovaRepublic of Mordovia Clinical Hospital №4.
I A FrolovaThe Volga District Medical Centre, Federal Medical and Biological Agency of Russia.
S M TsvingerChita State Medical Academy.
V V TsomaVolgograd State Medical University.
M B CholponbaevaNational Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov.
T Skikh I ChudinovskikhKirov State Medical University.
I V ShavrinMedsi.
O A ShevchenkoSBHI of Samara Region «Samara City Polyclinic №3».
D R ShikhalievPavlov First State Medical University of St. Petersburg.
E A ShishkinaPerm State Medical University named after E.A. Vagner.
K Yu ShishkovSamara State Medical University, Internal Diseases Department.
S Yu ShcherbakovKazan State Medical Academy.
G V ShcherbakovaSechenov University.
E A YaushevaPrivate Healthcare Institution «Clinical Hospital RZHD Meditsyna at Samara railway station».
Privolzhsky Research Medical University · RUNorth-Western State Medical University named after I.I. Mechnikov · RUFirst Pavlov State Medical University of St. Petersburg · RUSamara State Medical University · RUNational Center of Cardiology and Internal Medicine · KGKirov State Medical Academy · RUKazakh National Medical University · KZKrasnoyarsk State Medical University · RUPetrozavodsk State University · RUPirogov Russian National Research Medical University · RUSaratov State Medical University · RUFederal Medical-Biological Agency · RUN. I. Lobachevsky State University of Nizhny Novgorod · RURegional Public Health Care Institution "City Hospital No. 5, Barnaul" · RUChelyabinsk State Medical Academy · RUNational Research Mordovia State University · RUVolgograd State Medical University · RUChita State Academy of Medicine · RUCity Clinical Hospital · RUCity Hospital No. 40 · RU
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).
aimTo study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period. MATERIALS AND
methodsAKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666).
resultsA higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13-3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30-2,30).The patients with the 1st and 2nd degree obesity, undergoing the inpatient treatment, tended to have a higher probability of a mortality rate. While in case of morbid obesity patients this tendency is the most significant (odds ratio - 1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 yearsCONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.
Indexed as
COVID-19Body Mass IndexHospitalsHumansMiddle AgedObesityOverweightPatient DischargeSARS-CoV-2
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