Evidence map›Paper›PMID 36689709›Full record

Observational studyProblemy endokrinologii2022

[Survival predictors in patients with ectopic acth syndrome].

O O Golounina, Zh/ E Belaya, L Ya Rozhinskaya, M Yu Pikunov, A A Markovich, L K Dzeranova, E I Marova, N S Kuznetsov, V V Fadeev, G A Melnichenko and 1 more

Open access · diamondAbstract readObservational StudyEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Problemy endokrinologii, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

O O GolouninaI.M. Sechenov First Moscow State Medical University (Sechenov University).
Zh/ E BelayaEndocrinology Research Centre.
L Ya RozhinskayaEndocrinology Research Centre.
M Yu PikunovThe National Medical Research Center of Surgery named after A. V. Vishnevsky.
A A MarkovichThe National Medical Research Center of Oncology named after N. N. Blokhin.
L K DzeranovaEndocrinology Research Centre.
E I MarovaEndocrinology Research Centre.
N S KuznetsovEndocrinology Research Centre.
V V FadeevI.M. Sechenov First Moscow State Medical University (Sechenov University).
G A MelnichenkoEndocrinology Research Centre.
I I DedovEndocrinology Research Centre.
Endocrinology Research Center · RUSechenov University · RUNational Medical and Surgical Center named after N.I. Pirogov · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine significant factors affecting the survival of patients with ectopic ACTH syndrome (EAS). MATERIALS AND

methodsA multi-center, observational study with a retrospective analysis of patients with EAS. The end point of the study was the fatal outcome of patients from various causes. In order to identify predictors of survival or mortality, univariate and multifactorial Cox regression analyses were carried out. ROC-analysis was used to determine the prognostic threshold values of individual predictors. The survival analysis was carried out using the Kaplan-Mayer method. Statistical data processing was carried out by using IBM SPSS Statistics 23.

resultsThe age of patients at the time of diagnosis ranged from 12 to 76 years (Me 40 years [28;54]). The age of the studied population was 55 years [38; 64] for women and 42 years [32; 54] for men. The median period of observation was 50 months [13;91], with a maximum follow-up of 382 months. 92 patients (60,9%) had bronchopulmonary NET, 17 (11,3%) - thymic carcinoid, 8 - pancreatic NET, 5 -pheochromocytoma, 1- cecum NET, 1- appendix carcinoid tumor, 1 - medullary thyroid cancer and 26 (17,2%) patients had an occult NET. The primary tumor was removed in 101 patients (66,9%). Bilateral adrenalectomy was performed in 42 (27,8%) cases. Metastases were revealed in 23,2% (n=35) of patients. Relapse of the disease was observed in 24,4%, long-term remission was preserved in 64 patients (74,4%). Death occurred in 42 patients (28%). The average age of survivors was 47,0±15,2 versus 53,5±15,6 years for the deceased (p=0,022). The average survival time from diagnosis for the deceased was 32 months, Me 16,5 months [7;54]. Multivariate analysis revealed that the following factors have a direct impact on survival: age of diagnosis ≥51 years (OR 4,493; 95% CI 2,056-9,818, p<0,001), bronchopulmonary neuroendocrine tumor (NET) (OR 0,281; 95% CI 0,119-0,665, p=0,004), the presence of distant metastases (OR 2,489; 95% CI 1,141-5,427, p=0,022), late-night salivary cortisol (LNSC) ≥122,2 nmol/L (OR 2,493; 95% CI 1,014-6,128, p=0,047).

conclusionThe prognosis of patients with EAS is influenced by the age of diagnosis, NET localization, distant metastases and level of LNSC. The most common cause of ectopic ACTH syndrome was bronchopulmonary NET which was associated with the best survival rate.

Indexed as

ACTH Syndrome, EctopicAdrenal Gland NeoplasmsCarcinoid TumorNeuroendocrine TumorsAdolescentAdultAgedChildFemaleHumansInfant, NewbornMaleMiddle AgedRetrospective StudiesYoung Adult

Identifiers

PMID36689709
PMCPMC9939959
OpenAlexW4317871104

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.