Observational studyJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023
Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study.
Observational study in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Glycemic Indices and Polysomnographic Parameters in an Iranian Population Referred to a Sleep Clinic.Sleep science (Sao Paulo, Brazil) · 2026Article
- Obstructive sleep apnea and selected comorbidities - a literature review of cohort studies.Archives of medical science : AMS · 2026Article
- Associations of polysomnographic measures of obstructive sleep apnea, and nocturnal oxygen saturation with incident type 2 diabetes mellitus in middle-aged and older men.Journal of sleep research · 2025Article
- Explainable Machine Learning Assists in Revealing Associations Between Polysomnographic Biomarkers and Incident Type 2 Diabetes in Men.Nature and science of sleep · 2025Article
- Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review.Reviews in cardiovascular medicine · 2024Review
- Obstructive Sleep Apnea: The Effect of Bariatric Surgery After Five Years-A Prospective Multicenter Trial.Obesity surgery · 2024Article
- Article
- The Contribution of Sleep Texture in the Characterization of Sleep Apnea.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
STUDY
objectivesWe sought to evaluate sleep measures that better predict incident diabetes and prediabetes in a large cohort of veterans.
methodsThis secondary analysis included 650 patients without baseline diabetes from a multisite observational veterans' cohort. Participants underwent obstructive sleep apnea evaluation via laboratory-based polysomnography between 2000 and 2004 with follow-up through 2012. The primary outcomes were prediabetes and diabetes defined by fasting blood glucose, hemoglobin A1c, or use of glucose-lowering medication at study initiation. Exposure variables included respiratory event frequency, arousals, and oxygen desaturation. Cox models adjusted for body mass index, age, race, sex, change in body mass index, and continuous positive airway pressure device utilization.
resultsThe adjusted analysis revealed that time spent with oxygen saturation less than 90 [hazards ratio (HR) 1.009], confidence interval (CI) 1.001-1.017,
conclusionsThere was no significant association of incident prediabetes or diabetes with AHI, the gold standard of sleep apnea severity. This study suggests that hypoxia may be a better predictor of glycemic outcomes than AHI in an obstructive sleep apnea population and may provide clues to the underlying mechanism(s) that link sleep-disordered breathing and its metabolic consequences. CITATION: Wojeck BS, Inzucchi SE, Qin L, Yaggi HK. Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study.
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