Evidence map›Paper›PMID 36688839›Full record

ArticleNano letters2023

Nanoparticle-Based Artificial Mitochondrial DNA Transcription Regulator:

Letao Yang, Christopher Rathnam, Takuya Hidaka, Yannan Hou, Brandon Conklin, Ganesh N Pandian, Hiroshi Sugiyama, Ki-Bum Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Letao YangDepartment of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-0572-9787
Christopher RathnamDepartment of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0003-3111-4687
Takuya HidakaDepartment of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Yannan HouDepartment of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.
Brandon ConklinDepartment of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-6834-3275
Ganesh N PandianDepartment of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
Hiroshi SugiyamaDepartment of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.ORCID 0000-0001-8923-5946
Ki-Bum LeeDepartment of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-8164-0047
Rutgers, The State University of New Jersey · USKyoto University · JP

Funding

Rutgers Optimizes Innovation (ROI) ProgramU01HL150852 · NHLBI · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI LIBUTTI, STEVEN K., PANETTIERI, REYNOLD ALEXANDER · 2019 to 2022
$4.4M
Machine learning-enabled Comparative Transcriptomic Profiling to Validate NanoScript-induced Inner Ear Hair CellsR01DC016612 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI KWAN, KELVIN Y., LEE, KIBUM · 2018 to 2022
$2.8M
Training in Translating Neuroscience to TherapiesT32NS115700 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MOURADIAN, M. MARAL · 2021 to 2025
$1.4M
Nanoparticle-based synthetic transcription factor to induce stem cell myogenesisR21AR071101 · NIAMS · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM · 2017 to 2018
$371k
NHLBI NIH HHS U01 HL150852NIAMS NIH HHS R21 AR071101NIDCD NIH HHS R01 DC016612NINDS NIH HHS T32 NS115700
6 · The paper itself

Abstract

The growing knowledge of the links between aberrant mitochondrial gene transcription and human diseases necessitates both an effective and dynamic approach to control mitochondrial DNA (mtDNA) transcription. To address this challenge, we developed a nanoparticle-based synthetic mitochondrial transcription regulator (

Indexed as

DNA, MitochondrialNanoparticlesBiological TransportHumansMitochondriaTranscription, GeneticDNA, MitochondrialArtificial transcription factorsMitochondria DNA (mtDNA) manipulationsMitochondria-targeted deliveryNanoclustersNanomedicine

Identifiers

PMID36688839
PMCPMC11823678
OpenAlexW4317779243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.