Evidence map›Paper›PMID 36688818›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2023

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.

Maja L Nybo, Jone M Kvam, John E Nielsen, Hanne Frederiksen, Katja Spiess, Kristian H R Jensen, Sarina Gadgaard, Anna L S Walser, Jesper S Thomsen, Pamela Cowin and 3 more

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  4. Article
  5. Complex G-protein signaling of the adhesion GPCR, ADGRA3.The Journal of biological chemistry · 2025
    Article
  6. Article
  7. Article
  8. Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Maja L NyboLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jone M KvamLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
John E NielsenDepartment of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Hanne FrederiksenDepartment of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Katja SpiessLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kristian H R JensenLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sarina GadgaardLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anna L S WalserLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jesper S ThomsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Pamela CowinDepartment of Cell Biology, New York University School of Medicine, New York, New York, USA.
Anders JuulDepartment of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Martin Blomberg JensenGroup of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Mette M RosenkildeLaboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKCopenhagen University Hospital · DKRigshospitalet · DKAarhus University · DKNew York University · US

Funding

Dansk Frie ForskningsrådDepartment of Defense W81XWH-17-1-0013 BC160959European Research Council, ERC 682549Kirsten and Freddy Johansens Foundation 2017-112697Lundbeck Foundation R268-2017-409Novo Nordisk Foundation NNF17OC0029222Novo Nordisk Foundation NNF20OC0059475Valter Alex Torbjørn Eichmuller 2020-117043
6 · The paper itself

Abstract

The adhesion receptor ADGRA3 (GPR125) is a known spermatogonial stem cell marker, but its impact on male reproduction and fertility has not been examined. Using a mouse model lacking Adgra3 (Adgra3

Indexed as

AzoospermiaInfertility, MaleEpididymisHumansMalePenetranceSemenadhesion G protein-coupled receptorejaculatory ductejaculatory duct obstructionestrogenGPR125infertilityseminal vesiclesWnt signaling

Identifiers

PMID36688818
PMCPMC10107928
OpenAlexW4317777338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.