Evidence map›Paper›PMID 36688793›Full record

ArticleRenal failure2023

Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study.

Vinant Bhargava, Priti Meena, Anil Kumar Bhalla, Devinder Singh Rana, Ashwani Gupta, Manish Malik, Anurag Gupta, Vaibhav Tiwari

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Article in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Vinant BhargavaInstitute of Renal Science, Sir Gangaram Hospital, New Delhi, India.
Priti MeenaAll India Institute of Medical Sciences, Bhubaneswar, India.ORCID 0000-0001-6073-8101
Anil Kumar BhallaInstitute of Renal Science, Sir Gangaram Hospital, New Delhi, India.
Devinder Singh RanaInstitute of Renal Science, Sir Gangaram Hospital, New Delhi, India.
Ashwani GuptaInstitute of Renal Science, Sir Gangaram Hospital, New Delhi, India.
Manish MalikInstitute of Renal Science, Sir Gangaram Hospital, New Delhi, India.
Anurag GuptaInstitute of Renal Science, Sir Gangaram Hospital, New Delhi, India.
Vaibhav TiwariInstitute of Renal Science, Sir Gangaram Hospital, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.

methodsA nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.

resultsAmongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6-156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)).In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03-1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.

conclusionThis study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs.

Indexed as

Kidney TransplantationVenous ThromboembolismVenous ThrombosisAdultCase-Control StudiesHumansPrevalenceRetrospective StudiesRisk FactorsChemoprophylaxisdeep vein thrombosiskidney transplant recipientvenous thromboembolic events

Identifiers

PMID36688793
PMCPMC9873273

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