Evidence map›Paper›PMID 36688700›Full record

ArticleBioinformatics (Oxford, England)2023

Cistrome Explorer: an interactive visual analysis tool for large-scale epigenomic data.

Sehi L'Yi, Mark S Keller, Ariaki Dandawate, Len Taing, Chen-Hao Chen, Myles Brown, Clifford A Meyer, Nils Gehlenborg

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Learnable and Expressive Visualization Authoring Through Blended Interfaces.IEEE transactions on visualization and computer graphics · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sehi L'YiDepartment of Biomedical Informatics, Harvard Medical School.ORCID 0000-0001-7720-2848
Mark S KellerDepartment of Biomedical Informatics, Harvard Medical School.
Ariaki DandawateDepartment of Data Science, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute.
Len TaingDepartment of Data Science, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute.
Chen-Hao ChenDepartment of Data Science, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute.
Myles BrownCenter for Functional Cancer Epigenetics, Dana-Farber Cancer Institute.ORCID 0000-0002-8213-1658
Clifford A MeyerDepartment of Data Science, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute.
Nils GehlenborgDepartment of Biomedical Informatics, Harvard Medical School.ORCID 0000-0003-0327-8297

Funding

Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8M
Developing Informatics Technologies to Model Cancer Gene RegulationU24CA237617 · NCI · DANA-FARBER CANCER INST · PI MEYER, CLIFFORD · 2019 to 2023
$3.6M
NCI NIH HHS U24 CA237617NHGRI NIH HHS T32 HG002295
6 · The paper itself

Abstract

summaryThe regulation of genes by cis-regulatory elements (CREs) is complex and differs between cell types. Visual analysis of large collections of chromatin profiles across diverse cell types, integrated with computational methods, can reveal meaningful biological insights. We developed Cistrome Explorer, a web-based interactive visual analytics tool for exploring thousands of chromatin profiles in diverse cell types. Integrated with the Cistrome Data Browser database which contains thousands of ChIP-seq, DNase-seq and ATAC-seq samples, Cistrome Explorer enables the discovery of patterns of CREs across cell types and the identification of transcription factor binding underlying these patterns. AVAILABILITY AND IMPLEMENTATION: Cistrome Explorer and its source code are available at http://cisvis.gehlenborglab.org/ and released under the MIT License. Documentation can be accessed via http://cisvis.gehlenborglab.org/docs/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

ChromatinEpigenomicsChromatin Immunoprecipitation SequencingDatabases, GeneticSequence Analysis, DNASoftwareChromatin

Identifiers

PMID36688700
PMCPMC9900209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.