Evidence map›Paper›PMID 36688684›Full record

ArticleAntimicrobial agents and chemotherapy2023

Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection.

Dereje A Negatu, Rubén González Del Río, Mónica Cacho-Izquierdo, David Barros-Aguirre, Joël Lelievre, Joaquín Rullas, Patricia Casado, Uday S Ganapathy, Matthew D Zimmerman, Martin Gengenbacher and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. A Review ofInternational journal of microbiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Toward better cures forClinical microbiology reviews · 2024
    Review
  8. Article
  9. Microbiology spectrum · 2024
    Article
  10. Review
  11. Therapy ofMicroorganisms · 2024
    Review
  12. Review
  13. TheAntimicrobial agents and chemotherapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Dereje A NegatuCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-9205-6842
Rubén González Del RíoGlobal Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
Mónica Cacho-IzquierdoGlobal Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid, Spain.ORCID 0000-0001-6270-5370
David Barros-AguirreGlobal Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid, Spain.ORCID 0000-0002-4099-0438
Joël LelievreGlobal Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
Joaquín RullasGlobal Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
Patricia CasadoGlobal Health Medicines R&D, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
Uday S GanapathyCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Matthew D ZimmermanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Martin GengenbacherCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-0208-5920
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-9470-5009
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-9604-9452
GlaxoSmithKline (Spain) · ESHackensack Meridian Health · USGeorgetown University · US

Funding

Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
NIAID NIH HHS R01 AI132374
6 · The paper itself

Abstract

The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus

Indexed as

Mycobacterium abscessusMycobacterium Infections, NontuberculousAnimalsAnti-Bacterial AgentsAzabicyclo CompoundsCarbapenemsDisease Models, AnimalLungMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsavibactamAzabicyclo CompoundsCarbapenemstebipenemARX-1796beta-lactambeta-lactamase inhibitornontuberculous mycobacteriaNTMtebipenem-pivoxil

Identifiers

PMID36688684
PMCPMC9933631
OpenAlexW4317751995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.