ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023
Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.Nature neuroscience · 2026Article
- A hypoxia-sensitive medullary nucleus modulates cerebral blood flow via a disynaptic pathway to cortex.bioRxiv : the preprint server for biology · 2026Article
- Sex-dependent locus coeruleus vulnerability in Alzheimer's disease: gut dysbiosis as a driver and probiotic intervention as rescue.Biology of sex differences · 2026Review
- Central cytometabolic functional vascular coupling in health and disease.npj metabolic health and disease · 2025Review
- Noradrenergic Slow Vasomotion: The Hidden Fluid Pump Linking Sleep, Brain Clearance, and Dementia Pathogenesis.International journal of molecular sciences · 2025Review
- Orexin effect on physiological pulsations of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Research developments in the neurovascular unit and the blood‑brain barrier (Review).Biomedical reports · 2025Review
- Pericytes in the brain and heart: functional roles and response to ischaemia and reperfusion.Cardiovascular research · 2025Review
- Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.Neurobiology of aging · 2025Article
- Article
- Isoflurane anesthesia alters 31P magnetic resonance spectroscopy markers compared to awake mouse brain.PloS one · 2025Article
- The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection.Cell reports. Medicine · 2024Article
- Serotonergic regulation of cortical neurovascular coupling and hemodynamics upon awakening from sleep in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Single-pericyte nanomechanics measured by contraction cytometry.APL bioengineering · 2024Article
- Modal Analysis of Cerebrovascular Effects for Digital Health Integration of Neurostimulation Therapies-A Review of Technology Concepts.Brain sciences · 2024Article
- Plastic vasomotion entrainment.eLife · 2024Article
- Modulatory effects of noradrenergic and serotonergic signaling pathway on neurovascular coupling.Communications biology · 2024Article
- Non-neuronal cholinergic system in the heart influences its homeostasis and an extra-cardiac site, the blood-brain barrier.Frontiers in cardiovascular medicine · 2024Review
- The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI.Frontiers in cellular neuroscience · 2024Article
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Noradrenaline (NA) release from locus coeruleus axons generates vascular contractile tone in arteriolar smooth muscle and contractile capillary pericytes. This tone allows neuronal activity to evoke vasodilation that increases local cerebral blood flow (CBF). Much of the vascular resistance within the brain is located in capillaries and locus coeruleus axons have NA release sites closer to pericytes than to arterioles. In acute brain slices, NA contracted pericytes but did not raise the pericyte cytoplasmic Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.