ArticleThe EMBO journal2023
C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.
Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation.Molecular biology and evolution · 2026Article
- Transcriptomic Adjustment to Decreasing Oxygen Reveals Novel Functional Strategies for Extreme Hypoxia Tolerance in the Copepod Tigriopus californicus.Genome biology and evolution · 2026Article
- MYRF drives heterochronic miRNAs and LIN-42, and amplifies oscillatory programs for stage transitions.bioRxiv : the preprint server for biology · 2026Article
- Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing inbioRxiv : the preprint server for biology · 2026Article
- A scheduler for rhythmic gene expression.Molecular systems biology · 2025Article
- Systematic identification of oscillatory gene expression in single cell types.bioRxiv : the preprint server for biology · 2025Article
- A scheduler for rhythmic gene expression.bioRxiv : the preprint server for biology · 2025Article
- Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging.bioRxiv : the preprint server for biology · 2025Article
- A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans.PLoS genetics · 2025Article
- A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage inbioRxiv : the preprint server for biology · 2024Article
- C. elegans epicuticlins define specific compartments in the apical extracellular matrix and function in wound repair.Development (Cambridge, England) · 2024Article
- The NHR-23-regulated putative protease inhibitorbioRxiv : the preprint server for biology · 2024Article
- The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.Genetics · 2024Review
- Dynamics of miRNA accumulation during C. elegans larval development.Nucleic acids research · 2024Article
- Storage cell proliferation during somatic growth establishes that tardigrades are not eutelic organisms.Biology open · 2024Article
- A circadian-like gene network programs the timing and dosage of heterochronic miRNA transcription during C. elegans development.Developmental cell · 2023Article
- Canalisation and plasticity on the developmental manifold of Caenorhabditis elegans.Molecular systems biology · 2023Article
- NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.Development (Cambridge, England) · 2023Article
- C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.The EMBO journal · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
C. elegans develops through four larval stages that are rhythmically terminated by molts, that is, the synthesis and shedding of a cuticular exoskeleton. Each larval cycle involves rhythmic accumulation of thousands of transcripts, which we show here relies on rhythmic transcription. To uncover the responsible gene regulatory networks (GRNs), we screened for transcription factors that promote progression through the larval stages and identified GRH-1, BLMP-1, NHR-23, NHR-25, MYRF-1, and BED-3. We further characterize GRH-1, a Grainyhead/LSF transcription factor, whose orthologues in other animals are key epithelial cell-fate regulators. We find that GRH-1 depletion extends molt durations, impairs cuticle integrity and shedding, and causes larval death. GRH-1 is required for, and accumulates prior to, each molt, and preferentially binds to the promoters of genes expressed during this time window. Binding to the promoters of additional genes identified in our screen furthermore suggests that we have identified components of a core molting-clock GRN. Since the mammalian orthologues of GRH-1, BLMP-1 and NHR-23, have been implicated in rhythmic homeostatic skin regeneration in mouse, the mechanisms underlying rhythmic C. elegans molting may apply beyond nematodes.
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