Evidence map›Paper›PMID 36688373›Full record

ArticleeLife2023

Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in

Nathaniel J Himmel, Akira Sakurai, Atit A Patel, Shatabdi Bhattacharjee, Jamin M Letcher, Maggie N Benson, Thomas R Gray, Gennady S Cymbalyuk, Daniel N Cox

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nathaniel J HimmelNeuroscience Institute, Georgia State University, Atlanta, Georgia.ORCID 0000-0001-7876-6960
Akira SakuraiNeuroscience Institute, Georgia State University, Atlanta, Georgia.ORCID 0000-0003-2858-1620
Atit A PatelNeuroscience Institute, Georgia State University, Atlanta, Georgia.
Shatabdi BhattacharjeeNeuroscience Institute, Georgia State University, Atlanta, Georgia.
Jamin M LetcherNeuroscience Institute, Georgia State University, Atlanta, Georgia.ORCID 0000-0003-3077-0615
Maggie N BensonNeuroscience Institute, Georgia State University, Atlanta, Georgia.
Thomas R GrayNeuroscience Institute, Georgia State University, Atlanta, Georgia.ORCID 0000-0002-6176-005X
Gennady S CymbalyukNeuroscience Institute, Georgia State University, Atlanta, Georgia.ORCID 0000-0002-1889-5397
Daniel N CoxNeuroscience Institute, Georgia State University, Atlanta, Georgia.ORCID 0000-0001-9191-9212
Georgia State University · US

Funding

Molecular and Computational Dissection of Cold NociceptionR01NS115209 · NINDS · GEORGIA STATE UNIVERSITY · PI GENNADY S CYMBALYUK, Daniel N Cox · 2019 to 2026
$3.5M
Georgia State University Initiative for Maximizing Student DevelopmentR25GM109442 · NIGMS · GEORGIA STATE UNIVERSITY · PI COX, DANIEL N, FRANTZ, KYLE J. · 2016 to 2020
$1.0M
Functional roles of chloride homeostasis and chloride ion channels in thermosensory nociceptionF31NS117087 · NINDS · GEORGIA STATE UNIVERSITY · PI HIMMEL, NATHANIEL JOHN · 2020 to 2021
$72k
NIGMS NIH HHS R25 GM109442NIH HHS NS115209NIH HHS NS117087NINDS NIH HHS F31 NS117087NINDS NIH HHS R01 NS115209
6 · The paper itself

Abstract

Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between potentially harmful and innocuous stimuli is broadly important for organismal survival. Moreover, disruptions in the capacity to differentiate between noxious and innocuous stimuli can result in neuropathic pain.

Indexed as

Drosophila ProteinsNeuralgiaAnimalsAnoctaminsChloridesDrosophilaNociceptionNociceptorsSensory Receptor CellsAnoctaminsChloridesDrosophila Proteinsanoctamin/TMEM16chloride physiologyD. melanogasterneurosciencenociceptionnociceptive sensitizationsensory multimodalitythermosensation

Identifiers

PMID36688373
PMCPMC9904763
OpenAlexW4317746424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.