Evidence map›Paper›PMID 36687677›Full record

ArticleFrontiers in nutrition2022

Nutrient combinations exhibit universal antianxiety, antioxidant, neuro-protecting, and memory-improving activities.

Bangcheng Zhao, Xiuzhen Jia, Haotian Feng, Cheng Tang, Yixin Huang, Zifu Zhao, Jingyu Hao, Haoqiu Li, Jinrui Du, Yan Liu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Bangcheng ZhaoLaboratory of Non-Human Primate Disease Modeling Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Xiuzhen JiaInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Haotian FengInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Cheng TangSichuan SAFE Pharmaceutical Technology Co., Ltd., Chengdu, China.
Yixin HuangDepartment of Biological Sciences, College of Biological Science and Technology, Agricultural University of Hunan, Changsha, China.
Zifu ZhaoInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Jingyu HaoInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Haoqiu LiInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Jinrui DuInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Yan LiuInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Xingyu BaoInner Mongolia Dairy Technology Research Institute Co., Ltd., Yili Innovation Center, Inner Mongolia Yili Industrial Group Co., Ltd., Hohhot, China.
Zhihui ZhongLaboratory of Non-Human Primate Disease Modeling Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yingqian ZhangLaboratory of Non-Human Primate Disease Modeling Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Qixing ZhongLaboratory of Non-Human Primate Disease Modeling Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Inner Mongolia Yili Industrial Group (China) · CNSichuan University · CNState Key Laboratory of BiotherapyHunan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety disorders are the most common mental disorders and, without proper treatment, may lead to severe conditions: e.g., somatic disorders or permanent damage to central nervous system. Although there are drugs in clinical trials, this study focuses on exploring the efficacy of nutrients in treating these diseases. We built different zebrafish models and screened several nutrient combinations for their antianxiety, antioxidant, neuro-protecting, and memory-improving activities. Our results showed that the combinations of nutrients (e.g., Walnut Peptides + Theanine at 14.2 + 33.3 μg/ml) have similar or better activities than the positive control drugs. In addition, we discovered that the effects of the nutrients in the above four aspects were universal and highly related. This study is noteworthy as it suggested that nutrients could be healthier and greener drug alternatives and provide similar or better universal treatments for anxiety and related conditions.

Indexed as

antianxietyantioxidantmemory-improvingneuroprotectionnutrientszebrafish

Identifiers

PMID36687677
PMCPMC9852889
OpenAlexW4313595612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.