Evidence map›Paper›PMID 36687665›Full record

ArticleBJA open2022

Airway driving pressure is associated with postoperative pulmonary complications after major abdominal surgery: a multicentre retrospective observational cohort study.

Nicholas J Douville, Timothy L McMurry, Jennie Z Ma, Bhiken I Naik, Michael R Mathis, DouglasA Colquhoun, Sachin Kheterpal, Nathan L Pace, Traci L Hedrick, Randal S Blank and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BJA open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07431242 (Time-Dependent Exposure to Intraoperative Mechanical Power and Driving Pressure and Postoperative Pulmonary Outcomes in Laparoscopic Surgery), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07431242 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Time-Dependent Exposure to Intraoperative Mechanical Power and Driving Pressure and Postoperative Pulmonary Outcomes in Laparoscopic Surgery

TypeobservationalSponsorIstinye UniversityRan2026 to 2026Enrolled90ConditionsPostoperative Pulmonary ComplicationsArmsIntraoperative Ventilatory Load Exposure (Mechanical Power and Driving Pressure)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Observational
  5. Article
  6. Article
  7. In-Hospital Mortality in Mechanically Ventilated Children With Severe Dengue Fever: Explanatory Factors in a Single-Center Retrospective Cohort From Vietnam, 2013-2022.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Article
  8. Observational
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Nicholas J DouvilleDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
Timothy L McMurryDepartment of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jennie Z MaDepartment of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Bhiken I NaikDepartment of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Michael R MathisDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
DouglasA ColquhounDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
Sachin KheterpalDepartment of Anesthesiology, Michigan Medicine, Ann Arbor, MI, USA.
Nathan L PaceDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
Traci L HedrickDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA.
Randal S BlankDepartment of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Multicenter Perioperative Outcomes Group (MPOG) Perioperative Clinical Research Committee
University of Virginia · USHealthcare Technology Innovation Centre · INMichigan Medicine · USUniversity of Michigan–Ann Arbor · USUniversity of Utah · US

Funding

Early Diagnosis of Heart Failure: A Perioperative Data-Driven ApproachK01HL141701 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATHIS, MICHAEL ROBERT · 2018 to 2022
$862k
Predicting Postoperative Acute Kidney Injury through Integration of Genetics and Electronic Health RecordsK08DK131346 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nicholas J Douville · 2022 to 2026
$839k
Data Driven Approaches to Improving Risk Prediction of Pulmonary Complications After Major Inpatient SurgeryK08HL159327 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLQUHOUN, DOUGLAS ALASTAIR · 2021 to 2025
$811k
NHLBI NIH HHS K01 HL141701NHLBI NIH HHS K08 HL159327NIDDK NIH HHS K08 DK131346
6 · The paper itself

Abstract

Background: High airway driving pressure is associated with adverse outcomes in critically ill patients receiving mechanical ventilation, but large multicentre studies investigating airway driving pressure during major surgery are lacking. We hypothesised that increased driving pressure is associated with postoperative pulmonary complications in patients undergoing major abdominal surgery. Methods: In this preregistered multicentre retrospective observational cohort study, the authors reviewed major abdominal surgical procedures in 11 hospitals from 2004 to 2018. The primary outcome was a composite of postoperative pulmonary complications, defined as postoperative pneumonia, unplanned tracheal intubation, or prolonged mechanical ventilation for more than 48 h. Associations between intraoperative dynamic driving pressure and outcomes, adjusted for patient and procedural factors, were evaluated. Results: Among 14 218 qualifying cases, 389 (2.7%) experienced postoperative pulmonary complications. After adjustment, the mean dynamic driving pressure was associated with postoperative pulmonary complications (adjusted odds ratio for every 1 cm H Conclusions: Dynamic airway driving pressure, but not tidal volume or PEEP, is associated with postoperative pulmonary complications in models controlling for a large number of risk predictors and covariates. Such models are capable of risk prediction applicable to individual patients.

Indexed as

abdominal surgerydriving pressurelung protective ventilationpostoperative pulmonary complicationspredictive modelsventilation-induced lung injury

Identifiers

PMID36687665
PMCPMC9853922
OpenAlexW4306748527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.