ArticleAsian journal of transfusion science
Distribution and frequency of principal Rh blood group antigens (D, C, c, E, and e) and their phenotypes in the blood donors attending blood bank in a tertiary care hospital in Barpeta district of Assam.
Article in Asian journal of transfusion science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Transfusion-induced hemolysis in warm autoimmune hemolytic anemia with autoantibodies that have anti-e specificity: a case report and systematic review of the literature.Therapeutic advances in hematology · 2026Article
- Establishment and application of suspension static method in blood group screening of automated blood group analyzer.Scientific reports · 2023Article
- Genotype analysis to clarify RhD variants in discrepant samples of Chilean population.Frontiers in immunology · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundThe ABO and Rhesus grouping system antigens have been found to have the highest immunogenicity and propensity to produce alloantibodies that cause most of the transfusion reactions. The Rhesus antigens that produce most of the immunogenic transfusion reactions are D, C, c, E, and e. Knowledge of the distribution of these Rh antigens in a population helps to render compatible blood in alloimmunized patients.
aimThe aim was to study the distribution and frequency of principal Rh blood group antigens (D, C, c, E, and e) and their phenotypes in the blood donors attending blood bank in a tertiary care hospital in Barpeta district of Assam. MATERIALS AND
methodsThe study was conducted in 315 voluntary blood donors in the blood bank of a tertiary care center. Rh-D typing was done by conventional tube method. Specific monoclonal antisera, i.e., anti-C, anti-c, anti-E, and anti-e, were used and tests were performed by conventional tube method for detection of the presence of rest of the major Rh antigens.
resultsThe samples were analyzed for the five major Rhesus antigens. "D" antigen was found to be the most common antigen (99.05%), followed by e (97.14%), C (92.38%), c (51.43%), and E (20.95%). In order of descending frequency, the most common phenotypes were DCCee - 45.71%, DCcee - 30.48%, DCcEe - 11.43%, DccEe - 4.76%, DCcEE - 1.90%, DCCEe - 1.90%, Dccee - 1.90%, DCCEE - 0.95%, and dccee - 0.95%.
conclusionD antigen is the most common antigen in our study population, whereas "e" antigen is the most common in most of the studies done from other parts of India. Data on frequencies of major Rh antigens in the local donor population will help in transfusing alloimmunized patients with corresponding antibody-negative blood ensuring blood safety.
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