Evidence map›Paper›PMID 36687434›Full record

ArticleFrontiers in medicine2022

Normal tension glaucoma: A dynamic optical coherence tomography angiography study.

Jan Van Eijgen, Alexander Heintz, Claire van der Pluijm, Margaux Delporte, Dries De Witte, Geert Molenberghs, João Barbosa-Breda, Ingeborg Stalmans

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jan Van EijgenDepartment of Neurosciences, Research Group of Ophthalmology, KU Leuven, Leuven, Belgium.
Alexander HeintzDepartment of Neurosciences, Research Group of Ophthalmology, KU Leuven, Leuven, Belgium.
Claire van der PluijmDepartment of Neurosciences, Research Group of Ophthalmology, KU Leuven, Leuven, Belgium.
Margaux DelporteLeuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium.
Dries De WitteLeuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium.
Geert MolenberghsLeuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium.
João Barbosa-BredaDepartment of Neurosciences, Research Group of Ophthalmology, KU Leuven, Leuven, Belgium.
Ingeborg StalmansDepartment of Neurosciences, Research Group of Ophthalmology, KU Leuven, Leuven, Belgium.
KU Leuven · BEHospital de São João · PTStatistics Belgium · BEUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Vascular dysregulation seems to play a role in the pathogenesis of glaucoma, in particular normal tension glaucoma (NTG). The development of optical coherence tomography angiography (OCTA) enabled the measurement of the retinal microvasculature non-invasively and with high repeatability. Nonetheless, only a few studies transformed OCTA into a dynamic examination employing a sympathomimetic stimulus. The goal of this study was to use this dynamic OCTA exam (1) to differentiate healthy individuals from glaucoma patients and (2) to distinguish glaucoma subcategories, NTG and high-tension primary open angle glaucoma (POAG). Methods: Retinal vessel density (VD) in NTG patients ( Results: At baseline, mean peripapillary VD was lower in POAG and NTG (42.6 and 48.5%) compared to healthy controls (58.1%; Conclusion: Retinal VD loss in glaucoma patients was confirmed and the necessity to correct for gender, age and especially MAP was established. Although replication in a larger population is necessary, OCTA might not be the most suitable method to dynamically evaluate the retinal microvasculature.

Indexed as

glaucomahand grip testmicrovasculatureoptical coherence tomography angiographyretinasympathomimetic stimulus

Identifiers

PMID36687434
PMCPMC9853195
OpenAlexW4313644886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.