Evidence map›Paper›PMID 36687160›Full record

ArticleExposome2023

Environmental chemicals and endogenous metabolites in bile of USA and Norway patients with primary sclerosing cholangitis.

Caroline W Grant, Brian D Juran, Ahmad H Ali, Erik M Schlicht, Jackie K Bianchi, Xin Hu, Yongliang Liang, Zachery Jarrell, Ken H Liu, Young-Mi Go and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Exposome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Caroline W GrantDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Brian D JuranDivision of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Ahmad H AliDivision of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0001-8553-7744
Erik M SchlichtDivision of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Jackie K BianchiDivision of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Xin HuClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, GA, USA, Atlanta.
Yongliang LiangClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, GA, USA, Atlanta.
Zachery JarrellClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, GA, USA, Atlanta.
Ken H LiuClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, GA, USA, Atlanta.
Young-Mi GoClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, GA, USA, Atlanta.ORCID https://orcid.org/0000-0003-3353-0844
Dean P JonesClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, GA, USA, Atlanta.
Douglas I WalkerDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gary W MillerDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID https://orcid.org/0000-0001-8984-1284
Trine FolseraasResearch Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.
Tom H KarlsenResearch Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.
Nicholas F LaRussoDivision of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Gregory J GoresDivision of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Arjun P AthreyaDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Konstantinos N LazaridisDivision of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-0437-681X
Emory University · USMayo Clinic in Arizona · USMayo Clinic · USOslo University Hospital · NOColumbia University · USIcahn School of Medicine at Mount Sinai · USUniversity of Missouri Hospital · US

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
Dissecting the pathogenesis and outcomes of PSC using multi-omics by studying the exposome and genomeRC2DK118619 · NIDDK · MAYO CLINIC ROCHESTER · PI LAZARIDIS, KONSTANTINOS N · 2018 to 2022
$7.8M
NIDDK NIH HHS RC2 DK118619NIEHS NIH HHS P30 ES019776
6 · The paper itself

Abstract

Primary sclerosing cholangitis (PSC) is a complex bile duct disorder. Its etiology is incompletely understood, but environmental chemicals likely contribute to risk. Patients with PSC have an altered bile metabolome, which may be influenced by environmental chemicals. This novel study utilized state-of-the-art high-resolution mass spectrometry (HRMS) with bile samples to provide the first characterization of environmental chemicals and metabolomics (collectively, the exposome) in PSC patients located in the United States of America (USA) (

Indexed as

bileexposomemachine learningmulti-omicsprimary sclerosing cholangitis

Identifiers

PMID36687160
PMCPMC9853141
OpenAlexW4313701986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.