Evidence map›Paper›PMID 36687123›Full record

ReviewWorld journal of gastroenterology2023

Modern drug discovery for inflammatory bowel disease: The role of computational methods.

Titilayo Omolara Johnson, Augustina Oduje Akinsanmi, Stephen Adakole Ejembi, Olugbenga Eyitayo Adeyemi, Jane-Rose Oche, Grace Inioluwa Johnson, Abayomi Emmanuel Adegboyega

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Special Issue "Drug Treatments for Inflammatory Bowel Diseases".Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Titilayo Omolara JohnsonDepartment of Biochemistry, University of Jos, Jos 930222, Plateau, Nigeria. titijohnson2004@yahoo.com.
Augustina Oduje AkinsanmiDepartment of Biochemistry, University of Jos, Jos 930222, Plateau, Nigeria.
Stephen Adakole EjembiDepartment of Biochemistry, University of Jos, Jos 930222, Plateau, Nigeria.
Olugbenga Eyitayo AdeyemiDepartment of Biochemistry, University of Jos, Jos 930222, Plateau, Nigeria.
Jane-Rose OcheDepartment of Biochemistry, University of Jos, Jos 930222, Plateau, Nigeria.
Grace Inioluwa JohnsonFaculty of Clinical Sciences, College of Health Sciences, University of Jos, Jos 930222, Plateau, Nigeria.
Abayomi Emmanuel AdegboyegaDepartment of Biochemistry, University of Jos, Jos 930222, Plateau, Nigeria.
University of Jos · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel diseases (IBDs) comprising ulcerative colitis, Crohn's disease and microscopic colitis are characterized by chronic inflammation of the gastrointestinal tract. IBD has spread around the world and is becoming more prevalent at an alarming rate in developing countries whose societies have become more westernized. Cell therapy, intestinal microecology, apheresis therapy, exosome therapy and small molecules are emerging therapeutic options for IBD. Currently, it is thought that low-molecular-mass substances with good oral bio-availability and the ability to permeate the cell membrane to regulate the action of elements of the inflammatory signaling pathway are effective therapeutic options for the treatment of IBD. Several small molecule inhibitors are being developed as a promising alternative for IBD therapy. The use of highly efficient and time-saving techniques, such as computational methods, is still a viable option for the development of these small molecule drugs. The computer-aided (

Indexed as

Inflammatory Bowel DiseasesDrug DiscoveryHumansIntestinesComputer-aided drug designGenome-wide association studyInflammatory bowel diseaseJanus KinaseMolecular dockingMolecular dynamics simulation

Identifiers

PMID36687123
PMCPMC9846937
OpenAlexW4313550893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.