Evidence map›Paper›PMID 36687005›Full record

ArticleOncoimmunology2023

Tao Xu, Philipp Karschnia, Bruno Loureiro Cadilha, Sertac Dede, Michael Lorenz, Niklas Seewaldt, Elene Nikolaishvili, Katharina Müller, Jens Blobner, Nico Teske and 15 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  10. New T-Cell Therapies for Brain Metastasis, CD133 in the Driver's Seat.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 2 countries.

Tao XuDepartment of Neurology, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Philipp KarschniaDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Bruno Loureiro CadilhaDepartment of Medicine IV, Division of Clinical Pharmacology and Center of Integrated Protein Science Munich, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Sertac DedeDepartment of Neurology, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Michael LorenzDepartment of Medicine I, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Niklas SeewaldtDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Elene NikolaishviliDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Katharina MüllerDepartment of Neurology, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Jens BlobnerDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Nico TeskeDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Julika J HeroldDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Kai RejeskiGerman Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
Sigrid LangerDepartment of Neurology, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Hannah ObeckDepartment of Medicine IV, Division of Clinical Pharmacology and Center of Integrated Protein Science Munich, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Theo LorenziniDepartment of Medicine IV, Division of Clinical Pharmacology and Center of Integrated Protein Science Munich, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Matthias MulazzaniImmunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Wenlong ZhangDepartment of Neurology, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Hellen Ishikawa-AnkerholdDepartment of Medicine I, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Veit R BuchholzInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universitaet Muenchen (TUM), Munich, Germany.
Marion SubkleweDepartment of Medicine III, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Niklas ThonDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Andreas StraubeDepartment of Neurology, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Joerg-Christian TonnDepartment of Neurosurgery, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Sebastian KoboldDepartment of Medicine IV, Division of Clinical Pharmacology and Center of Integrated Protein Science Munich, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Louisa von BaumgartenDepartment of Neurology, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DEDeutschen Konsortium für Translationale Krebsforschung · DECenter for Integrated Protein Science Munich · DEInstitute of Medical Microbiology and Hygiene · DEWalter and Eliza Hall Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer patients are at risk for brain metastases and often succumb to their intracranial disease. Chimeric Antigen Receptor (CAR) T-cells emerged as a powerful cell-based immunotherapy for hematological malignancies; however, it remains unclear whether CAR T-cells represent a viable therapy for brain metastases. Here, we established a syngeneic orthotopic cerebral metastasis model in mice by combining a chronic cranial window with repetitive intracerebral two-photon laser scanning-microscopy. This approach enabled

Indexed as

Brain NeoplasmsLung NeoplasmsAnimalsAntigens, NeoplasmCytotoxicity, ImmunologicEpithelial Cell Adhesion MoleculeImmunotherapy, AdoptiveMiceReceptors, Antigen, T-CellT-LymphocytesAntigens, NeoplasmEpithelial Cell Adhesion MoleculeReceptors, Antigen, T-Celladoptive immunotherapybrain metastasisCAR T-cellsCNS tumorhistologyin vivo microscopylung cancersurvival

Identifiers

PMID36687005
PMCPMC9851202
OpenAlexW4316036716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.